BENZYL GLYCIDYL ETHER

Base Information

• Chemical Name: BENZYL GLYCIDYL ETHER
• CAS No.: 89616-40-0
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 89616-40-0.mol

Synonyms:1-Benzyloxy-2,3-epoxypropane;3-Benzyloxy-1,2-epoxypropane;VITAS-BB TBB000194;2-(Benzyloxymethyl)oxirane;

Chemical Property of BENZYL GLYCIDYL ETHER

Chemical Property:

• Melting Point: 70-73 °C
• Refractive Index: n20/D 1.5170(lit.)
• Boiling Point: 252.736 °C
• Flash Point: >230 °F
• PSA: 21.76000
• Density: 1.077 g/mL at 25 °C(lit.)
• LogP: 1.60200

Purity/Quality:

99% ^*data from raw suppliers

Benzyl glycidyl ether 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL GLYCIDYL ETHER

There total 44 articles about BENZYL GLYCIDYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + (R)-oxiranemethanol (57044-25-4) → (S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.200800154

Reference yield: 97.0%

(R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate (23214-66-6) → (S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9)

Guidance literature:

With potassium carbonate; In methanol; 1.) -10 deg C, 2 h; 2.) r.t., 2 h;

DOI:10.1016/S0040-4039(00)99116-0

Reference yield: 95.0%

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + benzyl alcohol (100-51-6,185532-71-2) → (S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9)

Guidance literature:

(S)-epichlorohydrin; With tetrabutylammomium bromide; sodium hydroxide; In water; at 20 ℃;

benzyl alcohol; In water; at 20 ℃; regioselective reaction;

DOI:10.1039/c2ob26329g

upstream raw materials:

(S)-Benzyl-(3-benzoyloxy-2-p-tosyloxy-propyl)-ether

benzyl allyl ether

(R)-3-benzyloxy-1,2-propanediol

(R)-3-(benzyloxy)-2-hydroxypropyl 4-methylbenzene sulfonate

Downstream raw materials:

(R)-1-benzyloxy-2-hydroxyhexadecane

(R)-5-Benzyloxy-2-(3,4-dimethoxy-phenyl)-4-hydroxy-pentanenitrile

(2S)-1-(Phenylmethoxy)-4-(phenylsulfonyl)-5-(trimethylsilyl)-2-pentanol

N-[2-Acetylamino-6-((S)-3-benzyloxy-2-hydroxy-propoxy)-phenyl]-acetamide

Refernces

• 1、 González-Gil, Inés,Zian, Debora,Vázquez-Villa, Henar,Hernández-Torres, Gloria,Martínez, R. Fernando,Khiar-Fernández, Nora,Rivera, Richard,Kihara, Yasuyuki,Devesa, Isabel,Mathivanan, Sakthikumar,Del Valle, Cristina Rosell,Zambrana-Infantes, Emma,Puigdomenech, María,Cincilla, Giovanni,Sanchez-Martinez, Melchor,Rodríguez De Fonseca, Fernando,Ferrer-Montiel, Antonio V.,Chun, Jerold,López-Vales, Rubén,López-Rodríguez, María L.,Ortega-Gutiérrez, Silvia. "A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration". supporting information. p. 2372 - 2390. Retrieved 2020/01/02.
• 2、 Li, Chuang,Kan, Ting-Ting,Hu, Die,Wang, Ting-Ting,Su, Yong-Jun,Zhang, Chen,Cheng, Jian-Qing,Wu, Min-Chen. "Improving the activity and enantioselectivity of PvEH1, a Phaseolus vulgaris epoxide hydrolase, for o-methylphenyl glycidyl ether by multiple site-directed mutagenesis on the basis of rational design". . . Retrieved 2019/08/01.