2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid

Base Information

• Chemical Name: 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid
• CAS No.: 1029714-88-2
• Molecular Formula: C₂₂H₁₄FN₅O₂
• Molecular Weight: 399.384
• Mol file: 1029714-88-2.mol

Synonyms:2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid

Chemical Property of 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2-Fluoro-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b][1,2,4]triazin-2-yl]benzoicacid 98.47% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid

There total 5 articles about 2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzoicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.8%

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile (1029714-87-1) → 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid (1029714-88-2)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 12h;

Reference yield:

6-bromoquinoline (5332-25-2) → 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid (1029714-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium diacetate; 9-bora-bicyclo[3.3.1]nonane

2: hydrogenchloride / ethyl acetate; water

3: chloroform

4: hydrogenchloride / water

With hydrogenchloride; palladium diacetate; 9-bora-bicyclo[3.3.1]nonane; In chloroform; water; ethyl acetate;

Reference yield:

6-(3,3-diethoxypropyl)quinoline (1197377-26-6) → 2-fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid (1029714-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate; water

2: chloroform

3: hydrogenchloride / water

With hydrogenchloride; In chloroform; water; ethyl acetate;

upstream raw materials:

2-fluoro-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzonitrile

6-bromoquinoline

6-(3,3-diethoxypropyl)quinoline

3-(quinolin-6-yl)propanal

Downstream raw materials:

2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide

Refernces

• 1、 Glaenzel, Ulrike,Jin, Yi,Hansen, Regine,Schroer, Kirsten,Rahmanzadeh, Gholamreza,Pfaar, Ulrike,Van Lier, Jan Jaap,Borell, Hubert,Meissner, Axel,Camenisch, Gian,Zhao, Sylvia. "Absorption, distribution, metabolism, and excretion of capmatinib (inc280) in healthy male volunteers and in vitro aldehyde oxidase phenotyping of the major metabolite". supporting information. p. 873 - 885. Retrieved 2020/10/14.
• 2、 -. "SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME". Page/Page column 28. . Retrieved 2009/12/05.