Pyrazine-2,6-dicarboxylic Acid

Base Information

• Chemical Name: Pyrazine-2,6-dicarboxylic Acid
• CAS No.: 940-07-8
• Molecular Formula: C6H4 N2 O4
• Molecular Weight: 168.109
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90469283
• Nikkaji Number: J803.142H
• Wikidata: Q72503338
• Mol file: 940-07-8.mol

Synonyms:Pyrazine-2,6-dicarboxylic Acid;940-07-8;2,6-Pyrazinedicarboxylic acid;SCHEMBL69399;Pyrazine-2,6-dicarboxylicAcid;DTXSID90469283;AMY30106;MFCD08694102;AKOS000279993;CS-W022938;TS-00144;A859593

Chemical Property of Pyrazine-2,6-dicarboxylic Acid

Chemical Property:

• Melting Point: 225 oC**
• Boiling Point: 491.3±45.0 °C(Predicted)
• PKA: 2.24±0.10(Predicted)
• PSA: 100.38000
• Density: 1.665±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• LogP: -0.12700
• Storage Temp.: 2-8°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 168.01710661
• Heavy Atom Count: 12
• Complexity: 186

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrazine-2,6-dicarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(C=N1)C(=O)O)C(=O)O

Technology Process of Pyrazine-2,6-dicarboxylic Acid

There total 7 articles about Pyrazine-2,6-dicarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethyl pyrazine-2,6-dicarboxylate (35042-26-3) → pyrazine-2,6-dicarboxylic acid (940-07-8)

Guidance literature:

dimethyl pyrazine-2,6-dicarboxylate; With sodium hydroxide; In tetrahydrofuran; water; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1039/c2nj40791d

Reference yield:

pyrazine-2,6-dicarbonitrile (70911-23-8) → pyrazine-2,6-dicarboxylic acid (940-07-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01174a041

Reference yield:

6-chloro-pyrazine-2-carboxylic acid methyl ester (23611-75-8) → pyrazine-2,6-dicarboxylic acid (940-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h

1.2: 20 h / Reflux

2.1: lithium carbonate / 0.5 h

2.2: 3 h / 0 °C

3.1: sodium hydroxide / water; tetrahydrofuran / 1 h

With lithium carbonate; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; mineral oil;

DOI:10.1039/c2nj40791d

upstream raw materials:

pyrazine-2,6-dicarbonitrile

2,3,5-pyrazine-tricarboxylic acid

dimethyl pyrazine-2,6-dicarboxylate

6-chloro-pyrazine-2-carboxylic acid methyl ester

Downstream raw materials:

bis(triphenylphosphine)(2,6-pyrazinedicarboxylato)copper(I)

Piperazin-2,6-dicarbonsaeure

Refernces