9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate

Base Information

• Chemical Name: 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate
• CAS No.: 6820-79-7
• Molecular Formula: C₁₉H₂₃NO₅
• Molecular Weight: 345.395
• Mol file: 6820-79-7.mol

Synonyms:9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate

Chemical Property of 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate

There total 6 articles about 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.8%

acetic anhydride (108-24-7) + hyoscine hydrobromide (114-49-8) → 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate (6820-79-7)

Guidance literature:

With sodium carbonate; 1.) 2 h, 110 deg C - 115 deg C; 2.) water;

Reference yield: 86.0%

acetyl chloride (75-36-5) + scopolamine (51-34-3,138-12-5,64069-63-2,124917-17-5) → 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate (6820-79-7)

Guidance literature:

acetyl chloride; scopolamine; for 1.5h; Heating;

With sodium carbonate;

DOI:10.3906/kim-1108-59

Reference yield:

acetic anhydride (108-24-7) → 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl-3'-(acetyloxy)-2'-phenyl propanoate (6820-79-7)

Guidance literature:

at 85 ℃;

upstream raw materials:

acetic anhydride

hyoscine hydrobromide

acetyl chloride

scopolamine

Downstream raw materials:

(S)-3-acetoxy-2-phenyl-propionic acid 9-(5-dimethylamino-naphthalene-1-sulfonyl)-(1rN,2tH,4tH,5cN)-3-oxa-9-aza-tricyclo[3.3.1.0^2,4]non-7t-yl ester

(-)-Formylnorscopollamin

Norscopolamine

(-)-Azoniaspiro-(norscopolamin-8,1'-pyrrolidin)-bromid

Refernces

• 1、 Banholzer,Pook. "The synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with particular consideration of the bronchospasmolytic compound (-)-N-ethylnorscopolamine methobromide (Ba 253 BR)". . p. 217 - 228. Retrieved 2007/10/02.