2-HYDROXY-6-METHYLBENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-6-METHYLBENZOIC ACID METHYL ESTER
• CAS No.: 33528-09-5
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• Hs Code.: 2918290000
• Mol file: 33528-09-5.mol

Synonyms:2,6-Cresoticacid, methyl ester (6CI,7CI,8CI); 2-Hydroxy-6-methylbenzoic acid methyl ester;Methyl 2-hydroxy-6-methylbenzoate; Methyl 6-methylsalicylate

Chemical Property of 2-HYDROXY-6-METHYLBENZOIC ACID METHYL ESTER

Chemical Property:

• PSA: 46.53000
• LogP: 1.48720
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

Methyl2-Hydroxy-6-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-hydroxy-6-methylbenzoate (cas# 33528-09-5) is used in the method for controlling ant colonies.

Technology Process of 2-HYDROXY-6-METHYLBENZOIC ACID METHYL ESTER

There total 23 articles about 2-HYDROXY-6-METHYLBENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-hydroxy-6-methylbenzoic acid (567-61-3) → methyl 6-methylsalicylate (33528-09-5)

Guidance literature:

In diethyl ether; at 0 ℃; for 2h;

DOI:10.1016/j.tet.2008.09.075

Reference yield: 93.0%

methyl 3-oxooctyl-7-enoate (71203-69-5) → methyl 6-methylsalicylate (33528-09-5)

Guidance literature:

With oxygen; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 45 ℃; for 23h; under 760.051 Torr; chemoselective reaction;

DOI:10.1016/j.tetlet.2019.05.041

Reference yield: 90.0%

methanol (67-56-1) + 2-hydroxy-6-methylbenzoic acid (567-61-3) → methyl 6-methylsalicylate (33528-09-5)

Guidance literature:

With sulfuric acid; for 27h; Heating;

DOI:10.1016/S0040-4020(01)82406-6

upstream raw materials:

methanol

2-hydroxy-6-methylbenzoic acid

2-hydroxy-6-methyl-4-(toluene-4-sulfonyloxy)-benzoic acid methyl ester

(E)-methyl 3-oxo-6-octenoate

Downstream raw materials:

2-ethoxy-6-methyl-benzoic acid methyl ester

methyl 2-(tert-butyldimethylsilyloxy)-6-methyl-benzoate

methyl 2-methoxymethyl-6-propargyloxybenzoate

methyl 2-hydroxy-6-methoxymethylbenzoate

Refernces

• 1、 Hayashi, Natsumi,Masuko, Takashi,Okada, Syo,Takabatake, Tetsuhiko,Tomita, Hiroki,Toyota, Masahiro. "Anticancer agent synthesis designed by artificial intelligence: Pd(OAc)2-catalyzed one-pot preparation of biphenyls and its application to a concise synthesis of various diazofluorenes". . . Retrieved 2020/09/01.
• 2、 Morack, Tobias,Metternich, Jan B.,Gilmour, Ryan. "Vitamin Catalysis: Direct, Photocatalytic Synthesis of Benzocoumarins via (-)-Riboflavin-Mediated Electron Transfer". supporting information. p. 1316 - 1319. Retrieved 2018/03/09.