(4-Fluorobenzyl)triphenylphosphonium chloride

Base Information

• Chemical Name: (4-Fluorobenzyl)triphenylphosphonium chloride
• CAS No.: 3462-95-1
• Molecular Formula: C25H21 F P . Cl
• Molecular Weight: 406.867
• Hs Code.: 2931900090
• European Community (EC) Number: 669-100-5
• DSSTox Substance ID: DTXSID80369940
• Mol file: 3462-95-1.mol

Synonyms:(4-Fluorobenzyl)triphenylphosphonium chloride;3462-95-1;(4-fluorophenylmethyl)triphenylphosphonium chloride;(4-fluorophenyl)methyl-triphenylphosphanium;chloride;Phosphonium, [(4-fluorophenyl)methyl]triphenyl-, chloride;4-fluorobenzyl triphenylphosphonium chloride;C25H21ClFP;SCHEMBL376693;DTXSID80369940;CBHDAHHYMRXLIP-UHFFFAOYSA-M;GULJCSOINTWKNF-UHFFFAOYSA-M;MFCD00031637;AKOS016003711;4-Fluorobenzyl triphenylphosphine chloride;p-fluorobenzyltriphenylphosphonium chloride;4-Fluorobenzyl triphenyl phosphoniumchloride;4-fluorobenzyltriphenyl phosphonium chloride;CS-0040954;FT-0604770;triphenyl(4-fluorobenzyl)-phosphonium chloride;triphenyl-(4-fluorobenzyl)-phosphonium chloride;(4-fluoro-benzyl)-triphenyl-phosphonium chloride;4-fluorophenylmethyl triphenylphosphonium chloride;(4-fluorophenyl)methyl-triphenylphosphanium,bromide;A874917;(4-fluorophenylmethyl)-triphenylphosphonium chloride;J-019681;[(4-FLUOROPHENYL)METHYL]TRIPHENYLPHOSPHANIUM CHLORIDE

Chemical Property of (4-Fluorobenzyl)triphenylphosphonium chloride

Chemical Property:

• Melting Point: 310-312°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 13.59000
• Density: g/cm³
• LogP: 2.32380
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 406.1053435
• Heavy Atom Count: 28
• Complexity: 378

Purity/Quality:

99% ^*data from raw suppliers

(4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM CHLORIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[P+](CC2=CC=C(C=C2)F)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-]

Technology Process of (4-Fluorobenzyl)triphenylphosphonium chloride

There total 3 articles about (4-Fluorobenzyl)triphenylphosphonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

triphenylphosphine (603-35-0) + 1-chloromethyl-4-fluorobenzene (352-11-4) → (4-fluorobenzyl)triphenylphosphonium chloride (3462-95-1)

Guidance literature:

In benzene; for 48h; Reflux;

DOI:10.1016/j.tet.2013.06.074

Reference yield:

4-fluorobenzylic alcohol (459-56-3) + triphenylphosphine (603-35-0) → (4-fluorobenzyl)triphenylphosphonium chloride (3462-95-1)

Guidance literature:

With hydrogenchloride; for 12h; Yield given; Heating;

DOI:10.1021/jo00073a023

Reference yield:

→ (4-fluorobenzyl)triphenylphosphonium chloride (3462-95-1)

Guidance literature:

upstream raw materials:

4-fluorobenzylic alcohol

triphenylphosphine

1-chloromethyl-4-fluorobenzene

Downstream raw materials:

1-Fluoro-4-((1E,3E,5E)-6-phenyl-hexa-1,3,5-trienyl)-benzene

1-fluoro-4-((1E,3E)-4-phenylbuta-1,3-dien-1-yl)benzene

(Z)-1-fluoro-4-(4-methoxystyryl)benzene

(E)-4-fluoro-4'-methoxystilbene

Refernces

• 1、 Ho, Jinn-Hsuan,Lee, Ya-Wen,Chen, Ying-Zhe,Chen, Pin-Sian,Liu, Wei-Qi,Ding, Yi-Shun. "A family of stilbene-ethers as photolabile protecting groups for primary alcohols offers controlled deprotection based on choice of wavelength". . p. 7325 - 7332. Retrieved 2013/08/23.
• 2、 Motoshima, Kazunori,Sugita, Kazuyuki,Hashimoto, Yuichi,Ishikawa, Minoru. "Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists". supporting information; experimental part. p. 3041 - 3045. Retrieved 2011/06/24.