1-(4-Bromobenzyl)-4-methylpiperazine

Base Information

• Chemical Name: 1-(4-Bromobenzyl)-4-methylpiperazine
• CAS No.: 368879-17-8
• Molecular Formula: C12H17 Br N2
• Molecular Weight: 269.184
• Hs Code.: 2933599090
• Mol file: 368879-17-8.mol

Synonyms:1-(4-Bromobenzyl)-4-methylpiperazine

Chemical Property of 1-(4-Bromobenzyl)-4-methylpiperazine

Chemical Property:

• Boiling Point: 325.3±27.0 °C(Predicted)
• PKA: 7.57±0.10(Predicted)
• PSA: 6.48000
• Density: 1.325±0.06 g/cm3(Predicted)
• LogP: 2.07230

Purity/Quality:

98%Min ^*data from raw suppliers

1-(4-Bromobenzyl)-4-methylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Bromobenzyl)-4-methylpiperazine

There total 4 articles about 1-(4-Bromobenzyl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-methyl-piperazine (109-01-3) + 1-bromomethyl-4-bromobenzene (589-15-1) → 4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8)

Guidance literature:

In 1,4-dioxane; at 0 - 25 ℃;

DOI:10.1039/c0cc04196c

Reference yield: 87.0%

1-methyl-piperazine (109-01-3) + 1-bromomethyl-4-bromobenzene (589-15-1) → 4-methylpiperazinium bromide (314732-98-4) + 4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8)

Guidance literature:

In 1,4-dioxane; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1039/c0cc00648c

Reference yield:

1-(4-bromobenzyl)piperazine (91345-62-9) + methyl iodide (74-88-4) → 4-[(4-methylpiperazin-1-yl)methyl]bromobenzene (368879-17-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm701018h

upstream raw materials:

formic acid

1-(4-bromobenzyl)piperazine

methyl iodide

1-methyl-piperazine

Downstream raw materials:

1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine

bis{4-[N-(N-methylpiperazinyl)methyl]phenyl}phosphine oxide

1,2-bis(bis{4-[(4-methylpiperazin-1-yl)methyl]phenyl}phosphino)ethane

(4-((4-methylpiperazin-1-yl)methyl)phenyl)boronic acid

Refernces

• 1、 -. "PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS". Paragraph 0162; 0172; 0173. . Retrieved 2018/03/25.
• 2、 -. "PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS". Page/Page column 26; 27. . Retrieved 2015/03/28.