AMpicillin EP IMpurity I

Base Information

• Chemical Name: AMpicillin EP IMpurity I
• CAS No.: 10001-82-8
• Molecular Formula: C₂₄H₂₆N₄O₅S
• Molecular Weight: 482.56
• Mol file: 10001-82-8.mol

Synonyms:6β-[(R)-2-((R)-2-amino-2-phenyl-acetylamino)-2-phenyl-acetylamino]-penicillanic acid

Chemical Property of AMpicillin EP IMpurity I

Chemical Property:

• Boiling Point: 863.8±65.0 °C(Predicted)
• PKA: 2.44±0.50(Predicted)
• Density: 1.43±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

AmpicillinAmino-benzeneacetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Ampicillin Amino-benzeneacetaldehyde can be used to develop HPLC methods that detect compounds or impurities related to ampicillin in bulk drug. Ampicillin Amino-benzeneacetaldehyde is a related compound of Ampicillin, a β-lactam antibiotic used for treating bacterial infection. Ampicillin interferes with cell wall synthesis in bacteria.

Technology Process of AMpicillin EP IMpurity I

There total 4 articles about AMpicillin EP IMpurity I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-Aminopenicillanic Acid (551-16-6) → 6β-[(R)-2-((R)-2-amino-2-phenyl-acetylamino)-2-phenyl-acetylamino]-penicillanic acid (10001-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: H₂O

With sodium hydroxide; In water;

DOI:10.1021/ja01072a055

Reference yield:

N-carboxy-(R)-phenylglycine anhydride (3412-49-5) → 6β-[(R)-2-((R)-2-amino-2-phenyl-acetylamino)-2-phenyl-acetylamino]-penicillanic acid (10001-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH

2: H₂O

With sodium hydroxide; In water;

DOI:10.1021/ja01072a055

Reference yield:

6-Aminopenicillanic Acid (551-16-6) + N-carboxy-(R)-phenylglycine anhydride (3412-49-5) → 6β-[(R)-2-((R)-2-amino-2-phenyl-acetylamino)-2-phenyl-acetylamino]-penicillanic acid (10001-82-8)

Guidance literature:

With sodium hydroxide; at 1 ℃; for 3h;

DOI:10.1021/ja01072a055

upstream raw materials:

6-Aminopenicillanic Acid

N-carboxy-(R)-phenylglycine anhydride

ampicillin