POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE

Base Information

• Chemical Name: POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE
• CAS No.: 374564-35-9
• Molecular Formula: C6H4 B Br F3 . K
• Molecular Weight: 262.906
• Hs Code.: 2931900090
• Mol file: 374564-35-9.mol

Synonyms:Borate(1-),(4-bromophenyl)trifluoro-, potassium, (T-4)- (9CI); potassium(4-bromophenyl)trifluoroborate

Chemical Property of POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE

Chemical Property:

• Melting Point: >300 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 2.50350
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Potassium (4-Bromophenyl)trifluoroborate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Potassium 4-bromophenyltrifluoroborate is used as potent boronic acid surrogates in Suzuki-Miyaura Cross-Coupling reactions.

Technology Process of POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE

There total 4 articles about POTASSIUM 4-BROMOPHENYLTRIFLUOROBORATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Bromophenylboronic acid (5467-74-3) → potassium 4-bromophenyltrifluoroborate (374564-35-9)

Guidance literature:

With potassium hydrogen difluoride; In methanol; at 0 - 20 ℃;

DOI:10.1021/ja807076d

Reference yield: 86.0%

1.4-dibromobenzene (106-37-6) → potassium 4-bromophenyltrifluoroborate (374564-35-9)

Guidance literature:

1.4-dibromobenzene; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

With potassium hydrogen difluoride; In tetrahydrofuran; hexane; at 20 ℃;

DOI:10.1021/ol901669k

Reference yield: 85.0%

potassium hydrogen difluoride (1256935-40-6) + 4-Bromophenylboronic acid (5467-74-3) → potassium 4-bromophenyltrifluoroborate (374564-35-9)

Guidance literature:

In methanol; water; at 20 ℃; for 2h;

DOI:10.1039/c9nj01772k

upstream raw materials:

4-Bromophenylboronic acid

1.4-dibromobenzene

potassium hydrogen difluoride

Downstream raw materials:

1,4-bromoiodobenzene

4-bromo-phenol

4-(4-bromophenyl)bromobenzene

isopropyl (R)-2-acetylamino-3-(4-bromophenyl)propanoate

Refernces

• 1、 Mazzotti, Anthony R.,Campbell, Michael G.,Tang, Pingping,Murphy, Jennifer M.,Ritter, Tobias. "Palladium(III)-catalyzed fluorination of arylboronic acid derivatives". supporting information. p. 14012 - 14015. Retrieved 2013/10/21.
• 2、 Liesen, André P.,Silva, Arisson T.,Sousa, Jokderléa C.,Menezes, Paulo H.,Oliveira, Roberta A.. "Copper-catalyzed amination of potassium aryl trifluoroborates using aqueous ammonia". supporting information; experimental part. p. 4240 - 4242. Retrieved 2012/08/28.