Technology Process of N,N-dibutyl-2-((4-methoxyphenyl)amino)-1-(3-(piperidin-1-yl)propyl)-1H-imidazo[4,5-c]pyridine-6-carboxamide
There total 7 articles about N,N-dibutyl-2-((4-methoxyphenyl)amino)-1-(3-(piperidin-1-yl)propyl)-1H-imidazo[4,5-c]pyridine-6-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen; lithium hydroxide / palladium 10% on activated carbon / water / 16 h / 40 - 70 °C / 2327.23 Torr
1.2: pH 3
2.1: potassium nitrate; sulfuric acid / 2.33 h / 20 - 75 °C
2.2: 12 h / 60 °C / Cooling with ice
2.3: Cooling with ice
3.1: 4-methylcyclohexene / palladium 10% on activated carbon / isopropyl alcohol / 12 h / 100 °C / Sealed tube
4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 65 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C
6.1: hydrogenchloride; water / 12 h / 70 °C
7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h
With
hydrogenchloride; 4-methylcyclohexene; sulfuric acid; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; dicyclohexyl-carbodiimide; lithium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium nitrate; sulfuric acid / 2.33 h / 20 - 75 °C
1.2: 12 h / 60 °C / Cooling with ice
1.3: Cooling with ice
2.1: 4-methylcyclohexene / palladium 10% on activated carbon / isopropyl alcohol / 12 h / 100 °C / Sealed tube
3.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 65 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C
5.1: hydrogenchloride; water / 12 h / 70 °C
6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h
With
hydrogenchloride; 4-methylcyclohexene; sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; dicyclohexyl-carbodiimide;
palladium 10% on activated carbon;
In
tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;