Flt-3 inhibitor

Base Information

• Chemical Name: Flt-3 inhibitor
• CAS No.: 301305-73-7
• Molecular Formula: C18H20 N2 O4 S
• Molecular Weight: 360.43
• European Community (EC) Number: 636-890-8
• DSSTox Substance ID: DTXSID60359965
• Wikidata: Q27077684
• NCI Thesaurus Code: C124800
• Pharos Ligand ID: 8XYC4D1LZ1A7
• ChEMBL ID: CHEMBL210833
• Mol file: 301305-73-7.mol

Synonyms:301305-73-7;TCS 359;Flt-3 inhibitor;2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide;TCS-359;2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide;2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;CHEMBL210833;TCS359;2-(3,4-Dimethoxyphenylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;FLT3 Inhibitor;MFCD00617269;Benzo[b]thiophene-3-carboxamide,2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-;FLT-3;Oprea1_063849;Oprea1_870745;GTPL5970;SCHEMBL8290405;CHEBI:93427;DTXSID60359965;HMS3229E07;HMS3269D21;HMS3413J11;HMS3653F21;HMS3677J11;BCP06929;BMA30573;EX-A2323;BDBM50185084;s8023;STK259280;2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide;AKOS000291740;CCG-101295;CS-1543;NCGC00167787-01;NCGC00167787-07;AC-32804;AS-55900;HY-13907;D5275;EU-0002533;Flt-3 Inhibitor - CAS 301305-73-7;SW007400-2;EC-000.2454;EN300-1590374;A876296;AG-690/09665048;SR-01000408796;J-017794;SR-01000408796-1;BRD-K81376179-001-01-4;Q27077684;Z27358591;F0161-0047;2-(3,4-dimethoxybenzamido)-5-methyl-4-propylthiophene-3-carboxamide;2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-[(3,4-dimethoxybenzene)amido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-{[(3,4-dimethoxyphenyl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide;2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide, >=98% (HPLC), solid

Chemical Property of Flt-3 inhibitor

Chemical Property:

• Vapor Pressure: 1.91E-08mmHg at 25°C
• Refractive Index: 1.644
• Boiling Point: 454.4°Cat760mmHg
• PKA: 12.43±0.20(Predicted)
• Flash Point: 228.6°C
• PSA: 118.89000
• Density: 1.328g/cm³
• LogP: 3.76860
• Storage Temp.: −20°C
• Sensitive.: Light Sensitive
• Solubility.: H2O:
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 360.11437830
• Heavy Atom Count: 25
• Complexity: 504

Purity/Quality:

98% min ^*data from raw suppliers

TCS 359 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
• Uses: Fms-like tyrosine kinase (FLT3) is a cell-surface receptor with important roles in stem cell development, hematopoiesis, and cancer. FLT3 Inhibitor is a cell-permeable, ATP-competitive inhibitor of FLT3 (IC50 = 27 nM) that blocks the proliferation of myelomonocytic leukemia MV4-11 cells (IC50 = 0.41 μM). It is selective for FLT3 over a panel of 22 other kinases. FLT3 Inhibitor synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells. TCS 359 is a potent inhibitor of FLT3 used in the treatment of leukemia.