Dynasore

Base Information

• Chemical Name: Dynasore
• CAS No.: 304448-55-3
• Molecular Formula: C18H14 N2 O4
• Molecular Weight: 322.32
• Mol file: 304448-55-3.mol

Synonyms:2-Naphthalenecarboxylicacid, 3-hydroxy-, [(3,4-dihydroxyphenyl)methylene]hydrazide (9CI); Dynasore

Chemical Property of Dynasore

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 8.49±0.35(Predicted)
• Flash Point: °C
• PSA: 102.15000
• Density: 1.36g/cm³
• LogP: 3.11140
• Storage Temp.: −20°C
• Solubility.: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml).
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 322.09535693
• Heavy Atom Count: 24
• Complexity: 470

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dynasore ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 50
• Safety Statements: 22-24/25-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O
• Description: Dynasore (304448-55-3) is a noncompetitive inhibitor of dynamin GTPase activity and blocks dynamin-dependent endocytosis in cells, including neurons. It inhibits the GTPase activity of dynamin1, dynamin2, and Drp1 (mitochondrial dynamin). It is cell permeable, fast acting (seconds) and reversible.1,2 Dynasore is a extremely useful tool for studying endocytosis and other cellular events which are dependent on dynamin.3-5
• Uses: Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.[Cayman Chemical] Dynamin Inhibitor I, Dynasore is an inhibitor of Dynamin I and Dynamin II.

Technology Process of Dynasore

There total 1 articles about Dynasore which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-hydroxy-2-naphthohydrazide (5341-58-2) + 3,4-dihydroxybenzaldehyde (139-85-5) → 3-hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide (304448-55-3)

Guidance literature:

With ammonium cerium (IV) nitrate; In ethanol; at 65 ℃; for 3h;

DOI:10.1016/j.bmcl.2010.06.092

upstream raw materials:

3-hydroxy-2-naphthohydrazide

3,4-dihydroxybenzaldehyde

Refernces