3-BROMO-2,6-DIFLUOROBENZALDEHYDE

Base Information

• Chemical Name: 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
• CAS No.: 398456-82-1
• Molecular Formula: C7H3 Br F2 O
• Molecular Weight: 221.001
• Hs Code.: 2913000090
• Mol file: 398456-82-1.mol

Synonyms:3-Bromo-2,6-difluorobenzaldehyde

Chemical Property of 3-BROMO-2,6-DIFLUOROBENZALDEHYDE

Chemical Property:

• Melting Point: 53-57°C
• Boiling Point: 223℃
• Flash Point: 89℃
• PSA: 17.07000
• Density: 1.758
• LogP: 2.53980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2,6-difluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-2,6-difluorobenzaldehyde is used as a pharmaceutical intermediate.

Technology Process of 3-BROMO-2,6-DIFLUOROBENZALDEHYDE

There total 2 articles about 3-BROMO-2,6-DIFLUOROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2,4-difluorobromobenzene (348-57-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-bromo-2,6-difluoro-benzaldehyde (398456-82-1)

Guidance literature:

2,4-difluorobromobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; for 0.5h;

Reference yield:

2,4-difluorobromobenzene (348-57-2) → 3-bromo-2,6-difluoro-benzaldehyde (398456-82-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; N-methyl-acetamide; water;

Reference yield: 100.0%

3-bromo-2,6-difluoro-benzaldehyde (398456-82-1) + methylmagnesium bromide (75-16-1) → 1-(3-bromo-2,6-difluorophenyl)ethan-1-ol (1387634-86-7)

Guidance literature:

3-bromo-2,6-difluoro-benzaldehyde; methylmagnesium bromide; In diethyl ether; at 5 ℃; for 0.583333h;

With water; In diethyl ether;

upstream raw materials:

2,4-difluorobromobenzene

N,N-dimethyl-formamide

Downstream raw materials:

(3-bromo-2,6-difluorophenyl)methanol

6-[3-(tert-Butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]-2-chloro-imidazo[1,2-a]pyridine

[2,6-difluoro-3-(3-methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol

5-[3-(tert-butyldimethylsilanyloxymethyl)-2,4-difluorophenyl]pyridin-2-ylamine

Refernces

• 1、 -. "ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS". Page/Page column 50. . Retrieved 2015/07/07.
• 2、 -. "Pharmaceutical compounds". . . Retrieved 2008/06/13.