DULOXETINE MALEATE

Base Information

• Chemical Name: DULOXETINE MALEATE
• CAS No.: 116817-86-8
• Molecular Formula: C₄H₄O₄*C₁₈H₁₉NOS
• Molecular Weight: 413.494
• Mol file: 116817-86-8.mol

Synonyms:(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate

Chemical Property of DULOXETINE MALEATE

Chemical Property:

• Melting Point: 120 - 130°C
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

Duloxetine Maleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Duloxetine Maleate is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) and is used as an antidepressant.

Technology Process of DULOXETINE MALEATE

There total 1 articles about DULOXETINE MALEATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Duloxetine (116539-58-3,116539-59-4,116539-60-7,116817-13-1) + maleic acid (110-16-7,26099-09-2) → (+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate (116817-86-8)

Guidance literature:

In ethyl acetate; at 20 - 45 ℃; for 5h;

Reference yield:

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate (116817-86-8) → Duloxetine (116539-58-3,116539-59-4,116539-60-7,116817-13-1)

Guidance literature:

With sodium hydroxide; In water; at 25 ℃; pH=12;

Reference yield:

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate (116817-86-8) → duloxetine hydrochloride (136434-34-9)

Guidance literature:

(+)-(S)-N-methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine maleate; With sodium hydroxide; In water; toluene; at 25 ℃; for 0.166667h; pH=11 - 12;

With hydrogenchloride; In ethanol; ethyl acetate; at 5 - 20 ℃; for 4.5h; Product distribution / selectivity;

upstream raw materials:

Duloxetine

maleic acid

Downstream raw materials:

duloxetine hydrochloride

(+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-1-naphthyl)-propylamine

Duloxetine

Refernces