Technology Process of (4bR,7S,8aS,9R)-7-(2-(benzyloxy)ethyl)-11-(cyclopropylmethyl)-8a-hydroxy-3-methoxy-8,8a9,10-tetrahydro-5H-9,4b-(epiminoethano)phenanthren-6(7H)-one
There total 11 articles about (4bR,7S,8aS,9R)-7-(2-(benzyloxy)ethyl)-11-(cyclopropylmethyl)-8a-hydroxy-3-methoxy-8,8a9,10-tetrahydro-5H-9,4b-(epiminoethano)phenanthren-6(7H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 60h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 48 h / 20 °C
2.1: hydrogenchloride / water; tetrahydrofuran / 60 h / 20 °C
With
hydrogenchloride; sodium hydride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: zinc; ammonium chloride / acetone; water / 4.5 h / 60 °C
2.1: caesium carbonate / tetrahydrofuran / 70 °C
3.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylsilane / tetrahydrofuran / 20 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 - -10 °C
4.2: -78 - 20 °C
5.1: toluene-4-sulfonic acid / toluene / 96 h / Reflux; Dean-Stark
6.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -78 - -30 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
7.2: 48 h / 20 °C
8.1: hydrogenchloride / water; tetrahydrofuran / 60 h / 20 °C
With
hydrogenchloride; triethylsilane; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; sodium hexamethyldisilazane; sodium hydride; diisobutylaluminium hydride; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; zinc;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;