Technology Process of (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione tosylate
There total 15 articles about (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione tosylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
isopropyl alcohol;
at 20 - 40 ℃;
for 0.5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen / bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-1-[(Sp)-2-(2-diphenylphosphinophenyl)ferrocenyl]ethyldicydohexylphosphine / dichloromethane; methanol / 18 h / 18751.9 Torr
2: hydrogenchloride / methanol / 1 h / 20 °C / Inert atmosphere
3: water; methanol / 48 h / 20 °C / Inert atmosphere
4: isopropyl alcohol / 0.5 h / 20 - 40 °C / Inert atmosphere
With
hydrogenchloride; hydrogen;
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-1-[(Sp)-2-(2-diphenylphosphinophenyl)ferrocenyl]ethyldicydohexylphosphine;
In
methanol; dichloromethane; water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate / toluene / 113 h / 20 °C / Reflux; Inert atmosphere
3.1: water; lithium hydroxide monohydrate / 1,4-dioxane / Inert atmosphere
3.2: pH 6 - 7 / Inert atmosphere
4.1: triethylamine; pivaloyl chloride / toluene / 22.5 h / 80 °C / Reflux; Inert atmosphere
5.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.5 h / -78 °C / Inert atmosphere
5.2: 1.83 h / -78 °C / Inert atmosphere
6.1: water / platinum tris(dimethylphosphine oxide) / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere
7.1: water / methanol / 2.5 h / 20 °C / Inert atmosphere
7.2: Inert atmosphere
8.1: water; methanol / 48 h / 20 °C / Inert atmosphere
9.1: isopropyl alcohol / 0.5 h / 20 - 40 °C / Inert atmosphere
With
lithium hydroxide monohydrate; water; pivaloyl chloride; potassium carbonate; triethylamine; lithium diisopropyl amide;
platinum tris(dimethylphosphine oxide);
In
tetrahydrofuran; 1,4-dioxane; methanol; hexanes; dichloromethane; water; isopropyl alcohol; toluene;