METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE
• CAS No.: 167027-30-7
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.20
• Hs Code.: 2933990090
• Mol file: 167027-30-7.mol

Synonyms:6-amino-1H-indole-2-carboxylic acid methyl ester; 1H-Indole-2-carboxylic acid,6-amino-,methyl ester; RW3523;

Chemical Property of METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE

Chemical Property:

• Boiling Point: 415.407 °C at 760 mmHg
• PKA: 16.20±0.30(Predicted)
• Flash Point: 205.031 °C
• PSA: 68.11000
• Density: 1.339 g/cm³
• LogP: 2.11790
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 6-amino-1H-indole-2-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE

There total 12 articles about METHYL 6-AMINO-1H-INDOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-Nitro-1H-indole-2-carboxylic acid methyl ester (136818-66-1) → methyl 6-amino-1H-indole-2-carboxylate (167027-30-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 0.5h; under 1551.49 Torr;

Reference yield: 81.0%

1-(tert-butyl) 2-methyl 6-amino-1H-indole-1,2-dicarboxylate (1049677-82-8) → methyl 6-amino-1H-indole-2-carboxylate (167027-30-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 78.0%

6-acetamidoindole-2-carboxylic acid methyl ester (1427164-16-6) → methyl 6-amino-1H-indole-2-carboxylate (167027-30-7)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h; Reflux;

upstream raw materials:

methyl 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylate

6-Nitro-1H-indole-2-carboxylic acid methyl ester

6-Nitro-1H-indole-2-carboxylic Acid

1-(1,1-dimethylethyl) 2-methyl 6-nitro-1H-indole-1,2-dicarboxylate

Downstream raw materials:

methyl 6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylate

6-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1H-indole-2-carboxylic acid

6-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate

Refernces

• 1、 -. "Substituted benzene and heterocyclic compound and its preparation method and application". . . Retrieved 2016/10/20.
• 2、 Ji, Xing-Yue,Xue, Si-Tu,Zhan, Yue-Chen,Shen, Jia-Jia,Wu, Lin-Tao,Jin, Jie,Wang, Zhen,Li, Zhuo-Rong. "Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives". . p. 409 - 418. Retrieved 2014/07/21.