Technology Process of 4-bromo-2-[[(2,4-difluorophenyl)methylene]amino]-5-fluorophenol
There total 3 articles about 4-bromo-2-[[(2,4-difluorophenyl)methylene]amino]-5-fluorophenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-amino-4-bromo-5-fluorophenol; 2,4-difluorobenzaldehyde;
With
toluene-4-sulfonic acid;
In
toluene;
for 0.5h;
Heating / reflux;
With
triethylamine;
In
toluene;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; nitric acid / dichloromethane; water / 1 h / 0 °C
2: sodium dithionite; water / ethanol / 1 h / Heating / reflux
3: toluene-4-sulfonic acid / toluene / 0.5 h / Heating / reflux; Dean-Stark apparatus
With
sodium dithionite; sulfuric acid; water; nitric acid;
toluene-4-sulfonic acid;
In
ethanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium dithionite; water / ethanol / 1 h / Heating / reflux
2: toluene-4-sulfonic acid / toluene / 0.5 h / Heating / reflux; Dean-Stark apparatus
With
sodium dithionite; water;
toluene-4-sulfonic acid;
In
ethanol; toluene;