4-FLUORONITROBENZENE

Base Information

• Chemical Name: 4-FLUORONITROBENZENE
• CAS No.: 178603-76-4
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.102
• Hs Code.: 2904909090
• Mol file: 178603-76-4.mol

Synonyms:4-FLUORONITROBENZENE

Chemical Property of 4-FLUORONITROBENZENE

Chemical Property:

• Vapor Pressure: 0.34mmHg at 25°C
• Melting Point: 21℃
• Refractive Index: 1.534
• Boiling Point: 206.5°C at 760 mmHg
• Flash Point: 83.3°C
• PSA: 45.82000
• Density: 1.337g/cm³
• LogP: 2.25710

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s): R20/21/22:
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:
• Safety Statements: S36/37:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORONITROBENZENE

There total 105 articles about 4-FLUORONITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(p-fluorophenyl)trimethylsilane (455-17-4) → fluorobenzene (462-06-6) + 4-Fluoronitrobenzene (350-46-9,178603-76-4)

Guidance literature:

With water; nitric acid; acetic anhydride; at 60 ℃; for 3h;

DOI:10.1016/S0022-1139(98)00253-X

Reference yield: 46.0%

4-nitro-aniline (100-01-6,104810-17-5) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 4-Fluoronitrobenzene (350-46-9,178603-76-4)

Guidance literature:

4-nitro-aniline; With calcium fluoride; sulfuric acid; sodium nitrite; In dichloromethane; at 0 ℃; for 0.25h;

With water; In dichloromethane; at 55 ℃; for 2h;

DOI:10.1039/a901187k

Reference yield: 38.0%

4-nitrophenyl sulfurofluoridate (51451-34-4) → 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + para-methoxynitrobenzene (100-17-4) + 4-Fluoronitrobenzene (350-46-9,178603-76-4)

Guidance literature:

With tetramethylammonium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.6b12911

upstream raw materials:

fluorobenzene

nitro acetate

4-nitrobenzenediazonium tetrafluoroborate

4-nitro-aniline

Downstream raw materials:

N-benzoyl-O-(4-nitro-phenyl)-tyrosine ethyl ester

N-formyl-O-(4-nitro-phenyl)-tyrosine ethyl ester

N-(4-nitro-phenyl)-sulfanilic acid

bis-(4-fluoro-phenyl)-arsinic acid

Refernces

• 1、 Ferm,VanderWerf. "-". . p. 4809. Retrieved 1950.
• 2、 Lapidus, A. L.,Pirozhkov, S. D.,Antipov, Yu. V.,Nefedov, O. M.,Politanskii, S. F.. "CATALYTIC SYNTHESIS OF FLUOROAROMATIC URETHANES IN THE PRESENCE OF SELENIUM-CONTAINING COMPOUNDS". . p. 1221 - 1223. Retrieved 1983.
• 3、 Sasson, Yoel,Negussie, Samuel,Royz, Michael,Mushkin, Noam. "Tetramethylammonium chloride as a selective and robust phase transfer catalyst in a solid-liquid halex reaction: The role of water". . p. 297 - 298. Retrieved 1996.
• 4、 Yasuda,Yamanaka,Kurihara,Saito. "On the rearrangement of o-nitroaniline in Schiemann reaction". . p. 209 - 211. Retrieved 1968.
• 5、 Fauziev, Ruslan V.,Kharchenko, Alexandr K.,Kuchurov, Ilya V.,Zharkov, Mikhail N.,Zlotin, Sergei G.. "Nitration of aromatics with dinitrogen pentoxide in a liquefied 1,1,1,2-tetrafluoroethane medium". . p. 25841 - 25847. Retrieved 2021/08/09.
• 6、 Hong, Cynthia M.,Whittaker, Aaron M.,Schultz, Danielle M.. "Nucleophilic Fluorination of Heteroaryl Chlorides and Aryl Triflates Enabled by Cooperative Catalysis". . p. 3999 - 4006. Retrieved 2021/03/09.