1,3-bis(ethyl carboximidate)bezene dihydrochloride

Base Information

• Chemical Name: 1,3-bis(ethyl carboximidate)bezene dihydrochloride
• CAS No.: 36438-66-1
• Molecular Formula: C₁₂H₁₆N₂O₂*2ClH
• Molecular Weight: 293.193
• Mol file: 36438-66-1.mol

Synonyms:1,3-bis(ethyl carboximidate)bezene dihydrochloride

Chemical Property of 1,3-bis(ethyl carboximidate)bezene dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-bis(ethyl carboximidate)bezene dihydrochloride

There total 2 articles about 1,3-bis(ethyl carboximidate)bezene dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzene-1,3-dicarbonitrile (626-17-5) + ethanol (64-17-5) → 1,3-bis(ethyl carboximidate)bezene dihydrochloride (36438-66-1)

Guidance literature:

With hydrogenchloride; acetic acid ester;

Reference yield:

1,3-benzenedicarboxylic acid dithioamide (3030-54-4) → 1,3-bis(ethyl carboximidate)bezene dihydrochloride (36438-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol; aqueous lead acetate

2: absolute acetic acid ester; hydrogen chloride

With hydrogenchloride; acetic acid ester; ethanol; lead(IV) tetraacetate;

Reference yield: 53.0%

1,3-bis(ethyl carboximidate)bezene dihydrochloride (36438-66-1) + (S)-3-amino-4-cyclohexyl-2-methylbutan-2-ol (741271-72-7) → (S,S)-1,3-bis(4'-cyclohexylmethyl-5',5'-dimethyl-2'-oxazolinyl)benzene

Guidance literature:

1,3-bis(ethyl carboximidate)bezene dihydrochloride; With potassium carbonate; In dichloromethane; water; for 0.166667h;

(S)-3-amino-4-cyclohexyl-2-methylbutan-2-ol; In chlorobenzene; for 16h; Heating;

DOI:10.1016/j.tetasy.2004.05.032

upstream raw materials:

benzene-1,3-dicarbonitrile

ethanol

1,3-benzenedicarboxylic acid dithioamide

Downstream raw materials:

chloroethane

isophthalamide

5,5'-benzene-1,3-diylbis(1,3,4-thiadiazol-2-amine)

1,3-bis(5-phenyl-1,3,4-oxadiazol-2-yl)benzene

Refernces

• 1、 Tydlitat, Jiri,Bures, Filip,Kulhanek, Jiri,Ruzicka, Ales. "1,2-disubstituted hexahydro-1 H -benzo[d]imidazoles: Synthesis, characterization, and stability". scheme or table. p. 3934 - 3940. Retrieved 2010/12/29.
• 2、 Zuev, Peter S.,Sheridan, Robert S.. "Substituent Control of Biscarbene Electronic Configurations: m-Phenylenebis(chloromethylene)". . p. 2267 - 2269. Retrieved 2007/10/02.