3-Fluoro-4-methylphenylmagnesium bromide

Base Information

• Chemical Name: 3-Fluoro-4-methylphenylmagnesium bromide
• CAS No.: 185077-02-5
• Molecular Formula: C7H6BrFMg
• Molecular Weight: 213.332
• Hs Code.: 29310099
• European Community (EC) Number: 886-551-5
• Mol file: 185077-02-5.mol

Synonyms:185077-02-5;3-Fluoro-4-methylphenylmagnesium bromide;3-Fluoro-4-methylphenylmagnesium bromide, 0.50 M in 2-MeTHF;3-FLUORO-2-METHYLPHENYLMAGNESIUM BROMID;magnesium;1-fluoro-2-methylbenzene-5-ide;bromide;MFCD01311470;Magnesium,bromo(3-fluoro-4-methylphenyl)-;bromo(3-fluoro-4-methylphenyl)magnesium;magnesium,1-fluoro-2-methylbenzene-5-ide,bromide;SCHEMBL635149;FGTAIRVIEJUZJO-UHFFFAOYSA-M;3-Fluoro-4-methylphenylmagnesium bromide 0.5 M in Tetrahydrofuran;AKOS015909253;(3-fluoro-4-methylphenyl)magnesiumbromide

Chemical Property of 3-Fluoro-4-methylphenylmagnesium bromide

Chemical Property:

• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 0.00000
• Density: 0.953 g/mL at 25 °C
• LogP: 2.77990
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: Reacts with water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 211.94873
• Heavy Atom Count: 10
• Complexity: 182

Purity/Quality:

98% purity ^*data from raw suppliers

3-Fluoro-4-methylphenylmagnesium bromide 0.5M solution in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F;C
• Hazard Codes: F,C,Xn
• Statements: 11-14/15-19-34-40-36/37
• Safety Statements: 16-26-33-36/37/39-43-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=[C-]C=C1)F.[Mg+2].[Br-]

Technology Process of 3-Fluoro-4-methylphenylmagnesium bromide

There total 1 articles about 3-Fluoro-4-methylphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-4-bromotoluene (51436-99-8) + magnesium (7439-95-4) → (3-fluoro-4-methylphenyl)magnesium bromide (185077-02-5)

Guidance literature:

With iodine; In tetrahydrofuran; for 1.66667h; Heating / reflux;

Reference yield: 100.0%

carbon dioxide (124-38-9,18923-20-1) + (3-fluoro-4-methylphenyl)magnesium bromide (185077-02-5) → 3-fluoro-4-methyl-benzoic acid (350-28-7)

Guidance literature:

carbon dioxide; (3-fluoro-4-methylphenyl)magnesium bromide; In tetrahydrofuran; at 20 ℃; under 3000.3 Torr; gas-liquid flow reactor assembly;

With polymer-supported sulfonic acid; In tetrahydrofuran;

DOI:10.1002/anie.201006618

Reference yield: 95.0%

1-quinolin-2-yl-ethanone (1011-47-8) + (3-fluoro-4-methylphenyl)magnesium bromide (185077-02-5) → 1-(3-fluoro-4-methylphenyl)-1-(quinolin-2-yl)ethan-1-ol

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201806956

upstream raw materials:

2-fluoro-4-bromotoluene

magnesium

Downstream raw materials:

4-allyl-2-fluoro-1-methylbenzene

(S)-6-(3-fluoro-4-methylphenyl)-3,3-dimethylpiperidin-2-one

3-(3-fluoro-4-methylphenyl)propan-1-ol

(3Z,11Z,16Z)-(5S,6S,7R,8R,9S,13S,14S,15S)-8,14-Bis-(tert-butyl-dimethyl-silanyloxy)-19-(3-fluoro-4-methyl-phenyl)-5,7,9,11,13,15-hexamethyl-nonadeca-1,3,11,16-tetraen-6-ol

Refernces