2-(Benzyloxy)-3-methoxybenzaldehyde

Base Information

• Chemical Name: 2-(Benzyloxy)-3-methoxybenzaldehyde
• CAS No.: 2011-06-5
• Molecular Formula: C15H14 O3
• Molecular Weight: 242.274
• Hs Code.: 29124900
• DSSTox Substance ID: DTXSID10361452
• Nikkaji Number: J261.131G
• Wikidata: Q63409355
• Mol file: 2011-06-5.mol

Synonyms:2-(benzyloxy)-3-methoxybenzaldehyde;2011-06-5;2-Benzyloxy-3-methoxybenzaldehyde;3-methoxy-2-phenylmethoxybenzaldehyde;2-Benzyloxy-3-methoxy-benzaldehyde;MFCD00202674;Benzaldehyde, 2-(benzyloxy)-3-methoxy-;benzyl-o-vanillin;3-methoxy-2-(phenylmethoxy)benzaldehyde;Oprea1_162681;Oprea1_847891;SCHEMBL1125006;benzyloxy-3-methoxy benzaldehyde;DTXSID10361452;2-benzyloxy-3-methoxyl-benzaldehyde;BBL013563;STK346681;AKOS000290582;2-Benzyloxy-3-methoxybenzaldehyde, 98%;3-Methoxy -2-(phenylmethoxy)benzaldehyde;BB 0243332;FT-0633976;6H-921;EN300-173094;N12144;AE-017/30049019;J-013025;2-Benzyloxy-3-methoxybenzaldehyde (benzyl-o-vanillin);Q63409355;Z57887975

Chemical Property of 2-(Benzyloxy)-3-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 3.43E-06mmHg at 25°C
• Melting Point: 44-46 °C(lit.)
• Refractive Index: 1.59
• Boiling Point: 386.9°C at 760 mmHg
• Flash Point: 179.3°C
• PSA: 35.53000
• Density: 1.154g/cm³
• LogP: 3.08670
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 242.094294304
• Heavy Atom Count: 18
• Complexity: 248

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzyloxy)-3-methoxybenzenecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OCC2=CC=CC=C2)C=O

Technology Process of 2-(Benzyloxy)-3-methoxybenzaldehyde

There total 9 articles about 2-(Benzyloxy)-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloride (100-44-7) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-benzyloxy-3-methoxybenzaldehyde (2011-06-5)

Guidance literature:

With potassium carbonate; In methanol; at 90 ℃; for 12h;

Reference yield: 99.2%

benzyl bromide (100-39-0) + 3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 2-benzyloxy-3-methoxybenzaldehyde (2011-06-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2013.06.016

Reference yield: 91.0%

3-methoxy-2-hydroxybenzaldehyde (148-53-8) + iodomethylbenzene (620-05-3) → 2-benzyloxy-3-methoxybenzaldehyde (2011-06-5)

Guidance literature:

With potassium carbonate; In acetone; for 43h; Heating;

DOI:10.1021/jo00172a032

upstream raw materials:

benzyl chloride

3-methoxy-2-hydroxybenzaldehyde

benzyl bromide

iodomethylbenzene

Downstream raw materials:

2-Methyl-4-(3-methoxy-2-benzyloxy-phenyl)-3-methoxycarbonyl-buten-⁽³⁾-saeure-⁽¹⁾

2-benzyloxy-2'-hydroxy-3-methoxy-chalcone

dimethyl 2-(2-(benzyloxy)-3-methoxybenzylidene)malonate

1-(2-(benzyloxy)-3-methoxyphenyl)hex-2-yn-1-one

Refernces

• 1、 -. "ANGIOTENSIN II RECEPTOR 2 ANTAGONIST SALT FORM AND CRYSTALLINE FORM, AND PREPARATION METHOD THEREFOR". Paragraph 0109-0110; 0118-0120. . Retrieved 2021/07/10.
• 2、 -. "CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST". Paragraph 0116; 0117. . Retrieved 2020/03/24.