2-Phenylazetidine

Base Information

• Chemical Name: 2-Phenylazetidine
• CAS No.: 22610-18-0
• Molecular Formula: C9H11N
• Molecular Weight: 133.193
• Hs Code.: 2933990090
• Mol file: 22610-18-0.mol

Synonyms:2-Phenylazetidine;

Chemical Property of 2-Phenylazetidine

Chemical Property:

• Vapor Pressure: 0.143mmHg at 25°C
• Refractive Index: 1.547
• Boiling Point: 216 °C at 760 mmHg
• PKA: 10.44±0.40(Predicted)
• Flash Point: 85.2 °C
• PSA: 12.03000
• Density: 1.015 g/cm³
• LogP: 2.04980
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Phenylazetidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenylazetidine

There total 3 articles about 2-Phenylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-phenylazetidin-2-one (5661-55-2) → 2-phenylazetidine (22610-18-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 4h; Heating / reflux;

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 2-phenylazetidine (22610-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethyl ether / 2 h / 25 °C / Inert atmosphere

1.2: 1 h / Cooling with ice

2.1: lithium aluminium tetrahydride / diethyl ether / 4 h / Reflux

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1039/c3cc48555b

Reference yield:

→ 2-phenylazetidine (22610-18-0)

Guidance literature:

2-Phenyl-azetidinon-(4), LiAlH4 mit folgender Hydrolyse (Temp. nicht ueber 5grad) (neben 3-Amino-3-phenyl-propanol);

upstream raw materials:

4-phenylazetidin-2-one

styrene

Downstream raw materials:

5-chloro-3-((2-phenylazetidin-1-yl)methyl)benzo[d]oxazol-2(3H)-one

1-tert-butyl-2-(methyldiphenylsilyl)-2-phenylazetidine-1-carboxylate

N-(tert-butoxycarbonyl)-2-phenylazetidine

Refernces

• 1、 Degennaro, Leonardo,Zenzola, Marina,Trinchera, Piera,Carroccia, Laura,Giovine, Arianna,Romanazzi, Giuseppe,Falcicchio, Aurelia,Luisi, Renzo. "Regioselective functionalization of 2-arylazetidines: Evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent". supporting information. p. 1698 - 1700. Retrieved 2014/02/14.
• 2、 -. "6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists". Page/Page column 18. . Retrieved 2008/12/08.