Technology Process of (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester
There total 3 articles about (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
desmethyl anethole trithione; ALPROSTADIL;
dmap;
In
tetrahydrofuran;
at 0 ℃;
Inert atmosphere;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran;
at 20 ℃;
for 15h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine hydrochloride / 0.42 h / 215 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / tetrahydrofuran / 15 h / 0 - 20 °C
With
pyridine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
dmap;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfur / ISOPROPYLAMIDE / 6 h / 145 °C
2: pyridine hydrochloride / 0.42 h / 215 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / tetrahydrofuran / 15 h / 0 - 20 °C
With
pyridine hydrochloride; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
dmap;
In
tetrahydrofuran; ISOPROPYLAMIDE;
