N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE

Base Information

• Chemical Name: N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE
• CAS No.: 23314-06-9
• Molecular Formula: C7H16 N2
• Molecular Weight: 128.22
• Hs Code.: 2925290090
• European Community (EC) Number: 626-571-1
• DSSTox Substance ID: DTXSID60334232
• Nikkaji Number: J267.219G
• Mol file: 23314-06-9.mol

Synonyms:Formamidine,N'-tert-butyl-N,N-dimethyl- (8CI); N,N-Dimethyl-N'-(tert-butyl)formamidine;N'-tert-Butyl-N,N-dimethylformamidine

Chemical Property of N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE

Chemical Property:

• Refractive Index: n20/D 1.445(lit.)
• Boiling Point: 137-140 °C(lit.)
• PKA: 12.23±0.50(Predicted)
• Flash Point: 94 °F
• PSA: 15.60000
• Density: 0.815 g/mL at 25 °C(lit.)
• LogP: 1.37480
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 98

Purity/Quality:

98%,99%, ^*data from raw suppliers

N’-tert-Butyl-N,N-dimethylformamidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 16-26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)N=CN(C)C
• Uses: Enamidine intermediates derived from this reagent and carbonyl compounds may be converted into homologated secondary amines, aldehydes or ketones.1 Review of formamidines as precursors to α-amino carbanions.2

Technology Process of N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE

There total 5 articles about N'-TERT-BUTYL-N,N-DIMETHYLFORMAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H17N2(1+)*CH3O4S(1-) → N,N-dimethyl-N'-tert-butylformamidine (23314-06-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja00543a051

Reference yield:

t-butylformamide (2425-74-3) + tetrakis(dimethylamino)titanium (3275-24-9) → N,N-dimethyl-N'-tert-butylformamidine (23314-06-9)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1021/jo00811a009

Reference yield:

N-tert-butyl-N',N'-dimethylthioharnstoff (14327-02-7) → N,N-dimethyl-N'-tert-butylformamidine (23314-06-9)

Guidance literature:

With peracetic acid;

upstream raw materials:

t-butylformamide

tetrakis(dimethylamino)titanium

N-tert-butyl-N',N'-dimethylthioharnstoff

tert-butyl isothiocyanate

Downstream raw materials:

pyrrolidine tert-butylformamidine

N'-tert-Butyl-N-[2-(2-chloro-phenyl)-ethyl]-N-methyl-formamidine

N-methyl-N-<(2-bromophenyl)ethyl>-N'-tert-butylformamidine

N-methyl-N-<(2-chloro-4,5-dimethoxyphenyl)ethyl>-N'-tert-butylformamidine

Refernces

• 1、 Meyers, A. I.,Hoeve, Wolter Ten. "α-Substitution of Amines via Dipole Stabilized Carbanions from Formamidines". . p. 7125 - 7126. Retrieved 2007/10/02.