Dansylleucine

Base Information

• Chemical Name: Dansylleucine
• CAS No.: 1100-22-7
• Molecular Formula: C18H24 N2 O4 S
• Molecular Weight: 364.46
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID30149092
• Nikkaji Number: J208.362K
• Wikidata: Q83014769
• Mol file: 1100-22-7.mol

Synonyms:dansyl-leucine;dansylleucine;dns-leucine

Chemical Property of Dansylleucine

Chemical Property:

• Melting Point: 126 °C
• Refractive Index: -9.5 ° (C=1, EtOH)
• Boiling Point: 545°Cat760mmHg
• Flash Point: 283.4°C
• PSA: 95.09000
• Density: 1.256g/cm³
• LogP: 4.15510
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 364.14567842
• Heavy Atom Count: 25
• Complexity: 556

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Dimethylaminonaphthalene-1-sulfonyl-L-leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NS(=O)(=O)C1=CC=CC2=C1C=CC=C2N(C)C
• Isomeric SMILES: CC(C)C[C@@H](C(=O)O)NS(=O)(=O)C1=CC=CC2=C1C=CC=C2N(C)C

Technology Process of Dansylleucine

There total 1 articles about Dansylleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dansyl-D,L-leucine (65452-14-4) → N-dansyl-L-leucine (1100-22-7) + dansyl-D-leucine (99388-22-4)

Guidance literature:

DOI:10.1021/ac950698c

Reference yield:

N-dansyl-L-leucine (1100-22-7) → (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-phenyl-propyl)-amide

Guidance literature:

N-dansyl-L-leucine; L-homophenylalaninamide-Sieber Resin; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 22 ℃; for 16h;

With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm020209i

Reference yield:

N-dansyl-L-leucine (1100-22-7) → (S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-4-methyl-pentanoic acid ((S)-2-benzyloxy-1-carbamoyl-ethyl)-amide

Guidance literature:

N-dansyl-L-leucine; R-benzyloxyglycinamide-Siber Resin; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 22 ℃; for 16h;

With trifluoroacetic acid; In dichloromethane; at 22 ℃; for 0.5h; Further stages.;

DOI:10.1021/jm020209i

upstream raw materials:

dansyl-D,L-leucine

Refernces

• 1、 Wu, Jingwei,Su, Ping,Guo, Danhua,Huang, Jun,Yang, Yi. "Cationic β-cyclodextrin-modified hybrid magnetic microspheres as chiral selectors for selective chiral absorption of dansyl amino acids". . p. 3630 - 3636. Retrieved 2014/08/05.
• 2、 Messina,Girelli,Flieger,Sinibaldi,Sedmera,Cvak. "Direct resolution of optically active isomers on chiral packings containing ergoline skeletons. 5. Enantioseparation of amino acid derivatives". . p. 1191 - 1196. Retrieved 2007/10/03.