1-(3,4-Dimethoxyphenyl)propan-1-ol

Base Information

• Chemical Name: 1-(3,4-Dimethoxyphenyl)propan-1-ol
• CAS No.: 10548-83-1
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID90386305
• Nikkaji Number: J1.194.358F
• ChEMBL ID: CHEMBL454239
• Mol file: 10548-83-1.mol

Synonyms:1-(3,4-dimethoxyphenyl)propan-1-ol;10548-83-1;1-(3',4'-dimethoxyphenyl)-1-propanol;alpha-ethylveratryl alcohol;1-(3,4-Dimethoxyphenyl)-1-propanol;Cambridge id 5654626;CHEMBL454239;SCHEMBL6055371;1-(3,4-dimethoxyphenyl)propanol;DTXSID90386305;NMYXSFKGIICIIM-UHFFFAOYSA-N;MFCD01117649;AKOS008968667;SB84620;alpha-Ethyl-3,4-dimethoxybenzyl Alcohol;CS-0335503;FT-0667375;Y14602

Chemical Property of 1-(3,4-Dimethoxyphenyl)propan-1-ol

Chemical Property:

• Melting Point: 36-38 °C
• Boiling Point: 300.6 °C at 760 mmHg
• PKA: 14.25±0.20(Predicted)
• Flash Point: 135.6 °C
• PSA: 38.69000
• Density: 1.06 g/cm³
• LogP: 2.14720
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 196.109944368
• Heavy Atom Count: 14
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3'',4''-Dimethoxyphenyl)-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=CC(=C(C=C1)OC)OC)O
• Uses: 1-(3'',4''-Dimethoxyphenyl)-1-propanol (cas# 10548-83-1) is a compound useful in organic synthesis.

Technology Process of 1-(3,4-Dimethoxyphenyl)propan-1-ol

There total 9 articles about 1-(3,4-Dimethoxyphenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 3,4-dimethoxyphenyl ketone (1835-04-7) → 1-(3,4-dimethoxyphenyl)propan-1-ol (10548-83-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 8h; Heating;

DOI:10.1021/np9805443

Reference yield: 81.0%

ethyl bromide (74-96-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3-(3,4-dimethoxyphenyl)pentan-3-ol (618056-30-7) + 1-(3,4-dimethoxyphenyl)propan-1-ol (10548-83-1)

Guidance literature:

ethyl bromide; With magnesium; In diethyl ether;

3,4-dimethoxy-benzaldehyde; In diethyl ether; toluene; at 20 ℃; for 14h;

DOI:10.1016/j.tet.2005.10.051

Reference yield: 63.0%

Methylisoeugenol (93-16-3) → 1-(3,4-dimethoxyphenyl)propan-1-ol (10548-83-1)

Guidance literature:

With sodium tetrahydroborate; oxygen; In tetrahydrofuran; at 60 ℃; for 40h; under 750.075 Torr;

DOI:10.1246/bcsj.20190251

upstream raw materials:

ethyl 3,4-dimethoxyphenyl ketone

ethylmagnesium iodide

3,4-dimethoxy-benzaldehyde

ethylmagnesium bromide

Downstream raw materials:

N-(2,2-Dimethoxy-ethyl)-N-[1-(3,4-dimethoxy-phenyl)-propyl]-C-phenyl-methanesulfonamide

ethyl 3,4-dimethoxyphenyl ketone

4-propyl-1,2-dimethoxybenzene

Methylisoeugenol

Refernces

• 1、 Zacchino, Susana A.,Lopez, Silvia N.,Pezzenati, German D.,Furlan, Ricardo L.,Santecchia, Carina B.,Munoz, Lorena,Giannini, Fernando A.,Rodriguez, Ana M.,Enriz, Ricardo D.. "In vitro evaluation of antifungal properties of phenylpropanoids and related compounds acting against dermatophytes". . p. 1353 - 1357. Retrieved 1999.
• 2、 Roberts, Jeffrey C.,Pincock, James A.. "Methoxy-substituted stilbenes, styrenes, and 1-arylpropenes: Photophysical properties and photoadditions of alcohols". . p. 1480 - 1492. Retrieved 2007/10/03.