N-(2-FUROYL)GLYCINE METHYL ESTER

Base Information

• Chemical Name: N-(2-FUROYL)GLYCINE METHYL ESTER
• CAS No.: 13290-00-1
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.164
• Hs Code.: 2932190090
• Mol file: 13290-00-1.mol

Synonyms:Glycine,N-2-furoyl-, methyl ester (7CI,8CI); N-(2-Furoyl)glycine methyl ester

Chemical Property of N-(2-FUROYL)GLYCINE METHYL ESTER

Chemical Property:

• Vapor Pressure: 9.51E-09mmHg at 25°C
• Melting Point: 63-65 °C(lit.)
• Refractive Index: 1.523
• Boiling Point: 73°Cat760mmHg
• PKA: 12.62±0.46(Predicted)
• Flash Point: 11.7°C
• PSA: 68.54000
• Density: 0.791g/cm³
• LogP: 0.57330
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

N-(2-Furoyl)glycineMethylEster ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(2-Furoyl)glycine Methyl Ester is an intermediate in synthesizing 2-Furoylglycine (F865225), which is an intermediate used to prepare non-nucleoside inhibitors of HCV NS5b RNA polymerase. It is also used in the synthesis of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.

Technology Process of N-(2-FUROYL)GLYCINE METHYL ESTER

There total 1 articles about N-(2-FUROYL)GLYCINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-furanoic acid (88-14-2) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → Furoylglycine methyl ester (13290-00-1)

Guidance literature:

glycine ethyl ester hydrochloride; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; at 0 ℃; for 0.166667h;

2-furanoic acid; In N,N-dimethyl-formamide; for 17h;

DOI:10.3390/molecules23040885

upstream raw materials:

2-furanoic acid

glycine ethyl ester hydrochloride

Refernces