5-METHYL-2-PHENYL-3-PYRAZOLIDINONE

Base Information

• Chemical Name: 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE
• CAS No.: 13292-56-3
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.218
• Hs Code.: 2933990090
• Mol file: 13292-56-3.mol

Synonyms:5-METHYL-2-PHENYL-3-PYRAZOLIDINONE;5-METHYL-2-PHENYL-3-PYRZOLIDINONE

Chemical Property of 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE

Chemical Property:

• Vapor Pressure: 0.00707mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 269.9°Cat760mmHg
• Flash Point: 117°C
• PSA: 32.34000
• Density: 1.126g/cm³
• LogP: 1.71020

Purity/Quality:

98%min ^*data from raw suppliers

5-Methyl-2-phenylpyrazolidin-3-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE

There total 9 articles about 5-METHYL-2-PHENYL-3-PYRAZOLIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(E)-1-Benzotriazol-1-yl-but-2-en-1-one + phenylhydrazine (100-63-0) → 5-methyl-2-phenylpyrazolidin-3-one (13292-56-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.5h; regioselective reaction; Reflux;

DOI:10.1055/s-0028-1083159

Reference yield:

edaravone (89-25-8) → 5-methyl-2-phenylpyrazolidin-3-one (13292-56-3)

Guidance literature:

With Pd-BaSO₄; acetic acid; at 70 - 80 ℃; Hydrogenation;

Reference yield:

2-butenoic acid (3724-65-0) + phenylhydrazine (100-63-0) → 5-methyl-2-phenylpyrazolidin-3-one (13292-56-3)

Guidance literature:

at 125 - 160 ℃;

upstream raw materials:

2-butenoic acid

phenylhydrazine

(Z)-but-2-enoic acid

crotonic acid methyl ester

Downstream raw materials:

edaravone

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

C₂₉H₂₅ClN₄O₃S

C₂₇H₂₃ClN₄O₄S

Refernces

• 1、 Wang, Xiaoxia,Wang, Wencun,Wen, Yihang,He, Liang,Zhu, Xiangming. "Facile and highly regiospecific synthesis of 2-aryl-substituted pyrazolidin-3-ones from α,β-unsaturated N-acylbenzotriazoles and arylhydrazines". experimental part. p. 3223 - 3228. Retrieved 2009/05/07.