N-(2-phenylethyl)-1,3-propanediamine

Base Information

• Chemical Name: N-(2-phenylethyl)-1,3-propanediamine
• CAS No.: 3936-51-4
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.277
• Mol file: 3936-51-4.mol

Synonyms:N-(2-phenylethyl)-1,3-propanediamine

Chemical Property of N-(2-phenylethyl)-1,3-propanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-phenylethyl)-1,3-propanediamine

There total 6 articles about N-(2-phenylethyl)-1,3-propanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylethanol (60-12-8) + 1,4-diaminobutane (110-60-1) → N-(2-phenylethyl)-1,3-propanediamine (3936-51-4)

Guidance literature:

2-phenylethanol; 1,4-diaminobutane; In ethanol; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.1c00503

Reference yield:

3-(2-phenylethylamino)propionitrile (1488-20-6) → N-(2-phenylethyl)-1,3-propanediamine (3936-51-4)

Guidance literature:

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; for 18h; Ambient temperature;

DOI:10.1021/jm00106a015

Reference yield:

phenethylamine (64-04-0) → N-(2-phenylethyl)-1,3-propanediamine (3936-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 18 h / Heating

2: LiAlH₄, AlCl₃ / diethyl ether / 18 h / Ambient temperature

With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; ethanol;

DOI:10.1021/jm00106a015

upstream raw materials:

2-phenylethyl chloride

Trimethylenediamine

3-(2-phenylethylamino)propionitrile

1-phenyl-2-bromoethane

Downstream raw materials:

N-(3-aminopropyl)-4-(1H-indol-3-yl)-N-phenethylbutanamide trifluoroacetic acid salt

N¹-phenethyl-N³-phenylpropane-1,3-diamine

N-<2-(3-phenethylhexahydropyrimidino)ethyl>propionanilide

N-<2-(3-phenethylhexahydropyrimidino)ethyl>aniline

Refernces

• 1、 Coustard, Jean-Marie,Soro, Yaya,Siaka, Sorho,Bamba, Fanté,Cousson, Alain. "Synthesis of 6- to 10-membered ring (E)- hydroxyiminohydroazaazoniabenzocycloalkenes derivative from cyclization of 2-nitromethylene-1-(ω-phenylalkyl)imidazolidine or 2-nitromethylene-1- (ω-phenylalkyl)hexahydropyrimidine in trifluoromethanesulfonic acid". . p. 3320 - 3328. Retrieved 2007/10/03.