N-METHYLFUROHYDROXAMIC ACID

Base Information

• Chemical Name: N-METHYLFUROHYDROXAMIC ACID
• CAS No.: 109531-96-6
• Molecular Formula: C₆H₇NO₃
• Molecular Weight: 141.126
• Hs Code.: 2932190090
• Mol file: 109531-96-6.mol

Synonyms:N-Methylfurohydroxamicacid

Chemical Property of N-METHYLFUROHYDROXAMIC ACID

Chemical Property:

• Vapor Pressure: 0.0151mmHg at 25°C
• Melting Point: 101 °C
• Refractive Index: 1.535
• Boiling Point: 245.7°C at 760 mmHg
• Flash Point: 102.4°C
• PSA: 53.68000
• Density: 1.3g/cm³
• LogP: 0.74080
• Water Solubility.: almost transparency in hot Water

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-MethylfurohydroxamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-METHYLFUROHYDROXAMIC ACID

There total 3 articles about N-METHYLFUROHYDROXAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-furancarbonyl chloride (527-69-5) + N-methylhydroxyamine hydrochloride (4229-44-1) → N-hydroxy-N-methyl-2-furancarboxamide (109531-96-6)

Guidance literature:

With potassium hydroxide; In methanol; 1.) 0 deg C, 5 min.; 2.) 0 deg C, 30 min.; room temp., 2 h;

DOI:10.1021/jo00092a007

Reference yield: 64.0%

N-methylhydroxyamine hydrochloride (4229-44-1) + 2-furoyl-1H-1,2,3-benzotriazole (144223-33-6) → N-hydroxy-N-methyl-2-furancarboxamide (109531-96-6) + N-[(2-furylcarbonyl)oxy]methanamine

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1055/s-2003-42488

Reference yield:

2-furanoic acid (88-14-2) → N-hydroxy-N-methyl-2-furancarboxamide (109531-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 18 h / 20 °C

2: 64 percent / Et₃N / tetrahydrofuran / 16 h / 20 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1055/s-2003-42488

upstream raw materials:

2-furancarbonyl chloride

N-methylhydroxyamine hydrochloride

2-furoyl-1H-1,2,3-benzotriazole

2-furanoic acid

Downstream raw materials:

N-isopropoxymethyl-N-benzyl-2-furancarboxamide

Refernces

• 1、 Katritzky, Alan R.,Kirichenko, Nataliya,Rogovoy, Boris V.. "Efficient Conversions of Carboxylic Acids into O-Alkyl, N-Alkyl and O,N-Dialkylhydroxamic Acids". . p. 2777 - 2780. Retrieved 2007/10/03.
• 2、 Nagarajan,Rajappa,Rajagopalan,Talwalkar. "Hydroxamic acid derivatives with potential antiinflammatory activity". . p. 222 - 229. Retrieved 2007/10/02.