(R)-3-Aminotetrahydrofuran tosylate

Base Information

• Chemical Name: (R)-3-Aminotetrahydrofuran tosylate
• CAS No.: 111769-27-8
• Molecular Formula: C₄H₉NO*C₇H₈O₃S
• Molecular Weight: 259.326
• Hs Code.: 29321900
• European Community (EC) Number: 695-209-2
• DSSTox Substance ID: DTXSID80557885
• Mol file: 111769-27-8.mol

Synonyms:111769-27-8;(R)-3-Aminotetrahydrofuran tosylate;(R)-TETRAHYDROFURAN-3-AMINE 4-METHYLBENZENESULFONATE;(R)-(+)-Tetrahydro-3-furylamine p-toluenesulfonate salt;(R)-(+)-3-AMINOTETRAHYDROFURAN TOLUENE-4-SULFONATE;4-methylbenzenesulfonic acid;(3R)-oxolan-3-amine;(R)-Tetrahydrofuran-3-amine-4-methylbenzenesulfonate;(R)-(-)-3-aminotetrahydrofuran toluene-4-sulfonate;MFCD00040622;3-Furanamine, tetrahydro-, (R)-, 4-methylbenzenesulfonate;SCHEMBL82778;DTXSID80557885;AKOS015840392;AKOS015899928;CS-W002189;AS-19335;AM20060485;(R)-3-Aminotetrahydrofuran-p-toluenesulfonate;(R)-3-aminotetrahydrofuran toluene-4-sulfonate;(r)-(+)-3-aminotetrahydrofuran p-toluenesulfonate;A894695;(R)-Tetrahydro-3-furylamine p-toluenesulfonate salt;J-502097;(3R)-OXOLAN-3-AMINE;PARA-TOLUENE SULFONATE;(3R)-tetrahydrofuran-3-amine 4-methylbenzenesulfonate;(R)-tetrahydrofuran-3-aminium 4-methylbenzenesulfonate;(r)-3-aminotetrahydrofuran p-toluene-sulfonic acid salt;(R)-(+)-tetrahydrofuran-3-amine 4-methyl-benzene-sulfonate;(R)-(+)-tetrahydrofuran-3-amine 4-methyl-benzenesulfonate;(R)-(+)-tetrahydrofuran-3-amine 4-methylbenzene-sulfonate;4-Methylbenzene-1-sulfonic acid--(3R)-oxolan-3-amine (1/1);(R)-(+)-Tetrahydro-3-furylamine p-toluenesulfonate salt, >=99.0% (T);(R)-(+)-Tetrahydro-3-furylamine p-toluenesulfonate;3-Furanamine, tetrahydro-, (3R)-, 4-methylbenzenesulfonate;(r)-(+)-3-aminotetrahydrofuran p-toluenesulfonate salt;(r)-(+)-tetrahydro-3-furylamine p-toluenesulfonate salt;(R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate

Chemical Property of (R)-3-Aminotetrahydrofuran tosylate

Chemical Property:

• Melting Point: 139-141 °C
• Boiling Point: 452.8 °C at 760 mmHg
• Flash Point: 227.7 °C
• PSA: 98.00000
• LogP: 2.75680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 259.08782920
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

98% ^*data from raw suppliers

(R)-Tetrahydrofuran-3-amine4-methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Statements: 22-36/38-43
• Safety Statements: 22-24/25-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1COCC1N
• Isomeric SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1COC[C@@H]1N

Technology Process of (R)-3-Aminotetrahydrofuran tosylate

There total 2 articles about (R)-3-Aminotetrahydrofuran tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

toluene-4-sulfonic acid (104-15-4) + R-3-(N-Tritylamino)tetrahydrofuran (111705-52-3) → (R)-3-aminotetrahydrofuranyl tosylate (111769-27-8,104530-80-5)

Guidance literature:

In isopropyl alcohol; for 0.5h; Heating;

Reference yield:

→ (R)-3-aminotetrahydrofuranyl tosylate (111769-27-8,104530-80-5)

Guidance literature:

Reference yield: 95.7%

1-methyl-5-(2-phenyl[1,2,4]triazolo[1,5-a]pyridin-7-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid (1380329-77-0) + (R)-3-aminotetrahydrofuranyl tosylate (111769-27-8,104530-80-5) → (R)-1-methyl-N-5-(2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N4-(tetrahydrofuran-3-yl)-1H-pyrazole-4,5-dicarboxamide (1380329-90-7)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; for 18h; Reflux;

upstream raw materials:

toluene-4-sulfonic acid

R-3-(N-Tritylamino)tetrahydrofuran

Downstream raw materials:

Tecadenoson

(R)-5-Nitro-2-(tetrahydro-3-furanylamino)-N-(1,3-benzodioxol-5-ylmethyl)benzamide

(R)-5-Cyano-N-(3,4-dimethoxybenzyl)-2-(tetrahydrofuran-3-ylamino)benzamide

4-((1R)-1-phenylethyl)-(2S)-2-(4-(N-((3R)-tetrahydrofuran-3-yl)amino)phenyl)-morpholine

Refernces

• 1、 Barlos, Kleomenis,Papaioannou, Dionysios,Voliotis, Stavros. "Application of N-Tritylmethionine in the Preparation of Heterocycles of Biological and Synthetic Interest". . p. 1127 - 1134. Retrieved 2007/10/02.