2,4-DIAMINO-6-ETHOXYPYRIMIDINE

Base Information

• Chemical Name: 2,4-DIAMINO-6-ETHOXYPYRIMIDINE
• CAS No.: 116436-03-4
• Molecular Formula: C₆H₁₀N₄O
• Molecular Weight: 154.172
• Hs Code.: 2933599090
• Mol file: 116436-03-4.mol

Synonyms:2,4-Diamino-6-ethoxypyrimidine;2,6-Diamino-4-ethoxypyrimidine;NSC 9305;

Chemical Property of 2,4-DIAMINO-6-ETHOXYPYRIMIDINE

Chemical Property:

• Vapor Pressure: 2.74E-07mmHg at 25°C
• Melting Point: 160 °C(Solv: water (7732-18-5))
• Refractive Index: 1.615
• Boiling Point: 420.8 °C at 760 mmHg
• PKA: 5.41±0.10(Predicted)
• Flash Point: 208.3 °C
• PSA: 87.05000
• Density: 1.274 g/cm³
• LogP: 1.20210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2,4-Diamino-6-ethoxypyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIAMINO-6-ETHOXYPYRIMIDINE

There total 6 articles about 2,4-DIAMINO-6-ETHOXYPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-chloro-pyrimidine-2,4-diyldiamine (156-83-2) + sodium ethanolate (141-52-6) → 6-ethoxypyrimidine-2,4-diamine (116436-03-4)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/jm501434y

Reference yield: 93.0%

guanidine nitrate (113-00-8) + Thiocyanessigsaeure-O-ethylester (119224-96-3) → 6-ethoxypyrimidine-2,4-diamine (116436-03-4)

Guidance literature:

In ethanol; Heating;

DOI:10.1002/ardp.19883211210

Reference yield: 75.0%

6-chloro-pyrimidine-2,4-diyldiamine (156-83-2) + ethanol (64-17-5) → 6-ethoxypyrimidine-2,4-diamine (116436-03-4)

Guidance literature:

With sodium hydride; for 6h; Reflux;

DOI:10.1016/j.bmc.2010.10.027

upstream raw materials:

6-chloro-pyrimidine-2,4-diyldiamine

ethanol

sodium ethanolate

guanidine nitrate

Downstream raw materials:

6-ethoxy-5-nitrosopyrimidine-2,4-diamine

Refernces

• 1、 Chang, Lei,Lee, Sang-Yong,Leonczak, Piotr,Rozenski, Jef,De Jonghe, Steven,Hanck, Theodor,Müller, Christa E.,Herdewijn, Piet. "Imidazopyridine- and purine-thioacetamide derivatives: Potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)". . p. 10080 - 10100. Retrieved 2015/02/05.
• 2、 De Jonghe, Steven,Marchand, Arnaud,Gao, Ling-Jie,Calleja, Agnes,Cuveliers, Eva,Sienaert, Ilse,Herman, Jean,Clydesdale, Gavin,Sefrioui, Hassane,Lin, Yuan,Pfleiderer, Wolfgang,Waer, Mark,Herdewijn, Piet. "Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4- dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents". scheme or table. p. 145 - 149. Retrieved 2011/02/25.