8-Bromo-6-methylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 8-Bromo-6-methylimidazo[1,2-a]pyridine
• CAS No.: 136117-93-6
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90568169
• Wikidata: Q72447191
• Mol file: 136117-93-6.mol

Synonyms:8-Bromo-6-methylimidazo[1,2-a]pyridine;136117-93-6;8-bromo-6-methyl-imidazo[1,2-a]pyridine;8-bromo-6-methylH-imidazo[1,2-a]pyridine;SCHEMBL2266179;DTXSID90568169;IEXMXPBKRWDOBC-UHFFFAOYSA-N;MFCD09258770;AKOS015834450;AS-9447;6-methyl-8-bromoimidazo[1,2-a]pyridine;BP-20261;CS-0084909;EN300-305472;J-519396

Chemical Property of 8-Bromo-6-methylimidazo[1,2-a]pyridine

Chemical Property:

• Refractive Index: 1.663
• PSA: 17.30000
• Density: 1.6 g/cm³
• LogP: 2.40520
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 209.97926
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%min ^*data from raw suppliers

8-Bromo-6-methylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN2C=CN=C2C(=C1)Br

Technology Process of 8-Bromo-6-methylimidazo[1,2-a]pyridine

There total 2 articles about 8-Bromo-6-methylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloroethanal (107-20-0) + 3-bromo-5-methylpyridin-2-amine (17282-00-7) → 8-bromo-6-methyl-imidazo<1,2-a>pyridine (136117-93-6)

Guidance literature:

In ethanol; for 24h; Reflux;

DOI:10.1016/j.bmc.2008.09.027

Reference yield:

3-bromo-5-methylpyridin-2-amine (17282-00-7) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 8-bromo-6-methyl-imidazo<1,2-a>pyridine (136117-93-6)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; Yield given. Multistep reaction; 1) H₂O, a) r.t., b) 80 deg C, 2) r.t.;

DOI:10.1248/cpb.39.1556

Reference yield:

8-bromo-6-methyl-imidazo<1,2-a>pyridine (136117-93-6) → 3-benzylsulfanylmethyl-8-bromo-6-methyl-imidazo[1,2-a]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. AcOH, AcONa / 100 °C

2: 92 percent / acetic acid / 2 h / 80 °C

With sodium acetate; acetic acid;

DOI:10.1021/jm981051y

upstream raw materials:

3-bromo-5-methylpyridin-2-amine

Bromoacetaldehyde diethyl acetal

2-chloroethanal

Refernces

• 1、 -. "PURINE DERIVATIVES AS KINASE INHIBITORS". Page/Page column 72. . Retrieved 2008/06/13.