4-CYANO-2-IODOPYRIDINE

Base Information

• Chemical Name: 4-CYANO-2-IODOPYRIDINE
• CAS No.: 114821-24-8
• Molecular Formula: C6H3IN2
• Molecular Weight: 230.008
• Hs Code.: 2933399090
• Mol file: 114821-24-8.mol

Synonyms:Isonicotinonitrile,2-iodo- (6CI);2-Iodoisonicotinonitrile;

Chemical Property of 4-CYANO-2-IODOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Melting Point: 80-82 °C
• Refractive Index: 1.669
• Boiling Point: 275.8 °C at 760 mmHg
• Flash Point: 120.6 °C
• PSA: 36.68000
• Density: 2.04 g/cm³
• LogP: 1.55788
• Storage Temp.: Keep Cold
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

4-Cyano-2-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CYANO-2-IODOPYRIDINE

There total 5 articles about 4-CYANO-2-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

→ 2-iodoisonicotinonitrile (114821-24-8)

Guidance literature:

With acetyl chloride; sodium iodide; In acetonitrile; at 20 ℃; for 3.5h;

Reference yield: 44.0%

pyridine-4-carbonitrile (100-48-1) → 2-iodoisonicotinonitrile (114821-24-8) + 3-iodoisonicotinonitrile (10386-28-4)

Guidance literature:

pyridine-4-carbonitrile; With (TMP)3CdLi; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

With iodine; In tetrahydrofuran; hexane;

DOI:10.1021/jo902385h

Reference yield:

2-iodopyridine (5029-67-4) → 2-iodoisonicotinonitrile (114821-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; aqueous hydrogen peroxide / Erwaermen des Reaktionsprodukts mit Salpetersaeure und Schwefelsaeure

2: FeSO₄; aqueous NH₃

3: NaNO₂; aqueous H₂SO₄; CuSO₄ / Diazotization_.Reagens 4: Kupfer-Pulver

With ammonium hydroxide; sulfuric acid; dihydrogen peroxide; copper(II) sulfate; iron(II) sulfate; acetic acid; sodium nitrite;

upstream raw materials:

2-iodo-pyridin-4-ylamine

potassium cyanide

2-iodopyridine

2-iodo-4-nitropyridine N-oxide

Downstream raw materials:

N-(4-chloro-3-fluorophenyl)-5-[(4-cyanopyridin-2-yl)amino]-3-methyl-1,2-thiazole-4-carboxamide

5-[(4-cyanopyridin-2-yl)amino]-N-(3,4-difluorophenyl)-3-methyl-1,2-thiazole-4-carboxamide

5-[(4-cyanopyridin-2-yl)amino]-N-(2-ethylphenyl)-3-methyl-1,2-thiazole-4-carboxamide

Refernces

• 1、 Bentabed-Ababsa, Ghenia,Ely, Sidaty Cheikh Sid,Hesse, Stephanie,Nassar, Ekhlass,Chevallier, Floris,Nguyen, Tan Tai,Derdour, Aicha,Mongin, Florence. "Direct metalation of heteroaromatic esters and nitriles using a mixed lithium-cadmium base. Subsequent conversion to dipyridopyrimidinones". experimental part. p. 839 - 847. Retrieved 2010/08/20.