2,4-Dimethylcinnamic acid

Base Information

• Chemical Name: 2,4-Dimethylcinnamic acid
• CAS No.: 1685-80-9
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2916399090
• Mol file: 1685-80-9.mol

Synonyms:Cinnamicacid, 2,4-dimethyl- (6CI,7CI,8CI);3-(2,4-Dimethylphenyl)acrylic acid;

Chemical Property of 2,4-Dimethylcinnamic acid

Chemical Property:

• Vapor Pressure: 0.000265mmHg at 25°C
• Melting Point: 179-180 °C
• Refractive Index: 1.592
• Boiling Point: 310 °C at 760 mmHg
• PKA: 4.60±0.13(Predicted)
• Flash Point: 215 °C
• PSA: 37.30000
• Density: 1.118 g/cm³
• LogP: 2.40120
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(2E)-3-(2,4-Dimethylphenyl)acrylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dimethylcinnamic acid

There total 13 articles about 2,4-Dimethylcinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

malonic acid (141-82-2) + 2,4-dimethylbenzaldehyde (15764-16-6) → 3-(2,4-Dimethylphenyl)-propensaeure (1685-80-9)

Guidance literature:

With piperidine; pyridine; at 80 ℃; for 48h;

DOI:10.1007/BF00807400

Reference yield: 74.0%

→ 3-(2,4-Dimethylphenyl)-propensaeure (1685-80-9)

Guidance literature:

Reference yield: 49.0%

→ 2,4-dimethylcinnamic acid (1685-80-9)

Guidance literature:

upstream raw materials:

malonic acid

2,4-dimethylbenzaldehyde

ammonia

2,4-dimethylbenzyl alcohol

Downstream raw materials:

2,4-dimethyl-cinnamyl alcohol

(E)-ethyl 3-(2,4-dimethylphenyl)acrylate

5-(2-(2,4-Dimethylcinnamoylamino)ethyl)-2-methoxybenzenesulfonamide

Refernces

• 1、 Gharui, Chandan,Singh, Shreya,Pan, Subhas Chandra. "Chiral phosphoric acid catalyzed enantioselective annulation of acyclic enecarbamates to: In situ -generated ortho -quinone methides". supporting information. p. 7272 - 7276. Retrieved 2017/09/25.
• 2、 -. "Bicyclic cyclohexylamines and their use as nmda receptor antagonists". Page 53. . Retrieved 2010/02/06.