C₇₃H₇₈N₇O₁₀PSi₂

Base Information

• Chemical Name: C₇₃H₇₈N₇O₁₀PSi₂
• CAS No.: 155933-78-1
• Molecular Formula: C₇₃H₇₈N₇O₁₀PSi₂
• Molecular Weight: 1300.61
• Mol file: 155933-78-1.mol

Synonyms:C₇₃H₇₈N₇O₁₀PSi₂

Chemical Property of C₇₃H₇₈N₇O₁₀PSi₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₃H₇₈N₇O₁₀PSi₂

There total 1 articles about C₇₃H₇₈N₇O₁₀PSi₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite) (104992-55-4,131349-35-4,131432-30-9) + <8-<(tert-butyldiphenylsilyl)oxy>quinolyl>methanol (155933-77-0) → C73H78N7O10PSi2 (155933-78-1)

Guidance literature:

With 1H-tetrazole;

Reference yield:

C73H78N7O10PSi2 (155933-78-1) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-tetrahydro-furan-3-yl ester 8-(tert-butyl-diphenyl-silanyloxy)-quinolin-2-ylmethyl ester 2-cyano-ethyl ester

Guidance literature:

With tert.-butylhydroperoxide; dichloro-acetic acid; Multistep reaction; 1.) CH₂Cl₂, 2,4,4-trimethylpentane, 0 deg C, 30 min, 2.) CH₂Cl₂, 2,4,4-trimethylpentane, RT, 2 min;

DOI:10.1021/ja9607300

Reference yield:

C73H78N7O10PSi2 (155933-78-1) → Phosphoric acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-3-yl ester 8-(tert-butyl-diphenyl-silanyloxy)-quinolin-2-ylmethyl ester 2-cyano-ethyl ester

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane;

upstream raw materials:

N⁶-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine 3'-O-(2-cyanoethyl N,N-diisopropylphosphoramidite)

<8-<(tert-butyldiphenylsilyl)oxy>quinolyl>methanol

Refernces

• 1、 Dempcy, Robert O.,Bruice, Thomas C.. "The negative charge of alkyl phosphate diesters and the slow-gaited hydrolysis of RNA and DNA. Catalysis of RNA hydrolysis through metal ion ligation to the ester >PO2- moiety". . p. 4511 - 4512. Retrieved 2007/10/02.