Methyl N,N-dimethylaminoacrylate

Base Information

• Chemical Name: Methyl N,N-dimethylaminoacrylate
• CAS No.: 999-59-7
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.159
• Hs Code.: 2922499990
• Mol file: 999-59-7.mol

Synonyms:Acrylicacid, 3-(dimethylamino)-, methyl ester (6CI,7CI,8CI);3-(N,N-Dimethylamino)acrylic acid methyl ester;Methyl3-(dimethylamino)acrylate;

Chemical Property of Methyl N,N-dimethylaminoacrylate

Chemical Property:

• Vapor Pressure: 2.05mmHg at 25°C
• Melting Point: 48-49 °C
• Refractive Index: 1.449
• Boiling Point: 163.6 °C at 760 mmHg
• PKA: 6.58±0.70(Predicted)
• Flash Point: 61.7 °C
• PSA: 29.54000
• Density: 0.979 g/cm³
• LogP: 0.23470

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-(dimethylamino)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl N,N-dimethylaminoacrylate

There total 22 articles about Methyl N,N-dimethylaminoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethylamine (109-89-7) + propynoic acid methyl ester (922-67-8) → methyl 3-(N,N-dimethylamino)-2-propenoate (999-59-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/ol034736n

Reference yield: 100.0%

dimethyl amine (124-40-3) + propynoic acid methyl ester (922-67-8) → methyl 3-(N,N-dimethylamino)-2-propenoate (999-59-7)

Guidance literature:

In diethyl ether; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.01.090

Reference yield: 94.0%

dimethyl amine (124-40-3) + propynoic acid methyl ester (922-67-8) → methyl (2E)-3-(dimethylamino)prop-2-enoate (999-59-7,20664-47-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

dimethyl amine

propynoic acid methyl ester

diethylamine

acetic acid methyl ester

Downstream raw materials:

dimethyl 1-methoxy-2-phenyl-1H-pyrrole-3,4-dicarboxylate

3-ethyl 4-methyl 1-methoxy-2-(4-nitrophenyl)-1H-pyrrole-3,4-dicarboxylate

3-ethyl 4-methyl 1-methoxy-2-(4-methoxyphenyl)-1H-pyrrole-3,4-dicarboxylate

3-ethyl 4-methyl 2-benzyl-1-methoxy-1H-pyrrole-3,4-dicarboxylate

Refernces

• 1、 Jiang, Chengzhou,Wu, Jiamin,Han, Jiabin,Chen, Kai,Qian, Yang,Zhang, Zhengyu,Jiang, Yaojia. "An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units". supporting information. p. 5710 - 5713. Retrieved 2021/06/16.
• 2、 Chen, Jie,Guo, Pan,Zhang, Jianguo,Rong, Jiaxin,Sun, Wangbin,Jiang, Yaojia,Loh, Teck-Peng. "Synthesis of Functionalized α-Vinyl Aldehydes from Enaminones". supporting information. p. 12674 - 12679. Retrieved 2019/08/07.