Pyridine-2-sulfonyl Chloride

Base Information

• Chemical Name: Pyridine-2-sulfonyl Chloride
• CAS No.: 66715-65-9
• Molecular Formula: C5H4ClNO2S
• Molecular Weight: 177.611
• European Community (EC) Number: 802-226-2
• DSSTox Substance ID: DTXSID20396412
• Nikkaji Number: J900.266I
• Wikidata: Q72504029
• Mol file: 66715-65-9.mol

Synonyms:Pyridine-2-sulfonyl Chloride;66715-65-9;2-Pyridinesulfonyl chloride;2-Pyridinesulfonylchloride;2-pyridylsulfonyl chloride;2-PYRIDINYLSULFONYL CHLORIDE;pyridinesulphonyl chloride;2-pyridinesulphonylchloride;2-pryidinesulfonyl chloride;2-pyridinesulphonyl chloride;2-Pyridine sulfonyl chloride;SCHEMBL23025;DTXSID20396412;JQJOGAGLBDBMLU-UHFFFAOYSA-N;BCP17138;MFCD01632222;PYRIDINE-2-SULPHONYL CHLORIDE;AKOS010078732;AB09523;AM101116;AS-47595;2-Pyridinesulfonyl Chloride, Technical Grade;CS-0048732;FT-0650176;FT-0654922;EN300-120428;F14522;A835529;J-524118;Pyridine-2-sulfonyl chloride;2-Pyridinesulfonyl Chloride

Chemical Property of Pyridine-2-sulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 284.162 °C at 760 mmHg
• PKA: -5.12±0.19(Predicted)
• Flash Point: 125.657 °C
• PSA: 55.41000
• Density: 1.489 g/cm³
• LogP: 2.08990
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.9651272
• Heavy Atom Count: 10
• Complexity: 196

Purity/Quality:

99% ^*data from raw suppliers

2-PyridinesulfonylChloride,TechnicalGrade ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)S(=O)(=O)Cl

Technology Process of Pyridine-2-sulfonyl Chloride

There total 12 articles about Pyridine-2-sulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) → pyridine-2-sulfonyl chloride (66715-65-9)

Guidance literature:

With hydrogenchloride; chlorine; at 5 ℃; for 0.5h;

DOI:10.1021/jo00263a024

Reference yield: 96.0%

→ pyridine-2-sulfonyl chloride (66715-65-9)

Guidance literature:

Reference yield: 78.0%

2,2'-dipyridyldisulphide (2127-03-9) → 2-chloropyridine (109-09-1) + pyridine-2-sulfonyl chloride (66715-65-9)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid; In dichloromethane; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.11.047

upstream raw materials:

2-Sulfanylpyridine

hydrogenchloride

chlorine

2-bromo-pyridine

Downstream raw materials:

pyridine-2-sulfonic acid-[2]pyridylamide

pyridine-2-sulfonic acid dimethylamide

N-Phenylpyridine-2-sulfonamide

2-pyridinesulfonamide

Refernces

• 1、 Li, Mo,Bernhard, Stefan. "Synthetically tunable iridium(III) bis-pyridine-2-sulfonamide complexes as efficient and durable water oxidation catalysts". . p. 19 - 27. Retrieved 2017.
• 2、 Xu, Dong,Yang, Shiyi,Gao, Aijun,Yang, Zhanhui. "NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides". . p. 463 - 473. Retrieved 2020/07/03.
• 3、 Martínez-Mingo, Mario,Rodríguez, Nuria,Gómez Arrayás, Ramón,Carretero, Juan C.. "Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives". supporting information. p. 4345 - 4349. Retrieved 2019/06/14.