7-Quinolinecarboxylic acid

Base Information

• Chemical Name: 7-Quinolinecarboxylic acid
• CAS No.: 1078-30-4
• Molecular Formula: C10H7NO2
• Molecular Weight: 173.171
• Hs Code.: 29334900
• Mol file: 1078-30-4.mol

Synonyms:AKOS BBS-00005341;quinoline-7-carboxylic acid;

Chemical Property of 7-Quinolinecarboxylic acid

Chemical Property:

• Vapor Pressure: 1.85E-05mmHg at 25°C
• Melting Point: 249.5°C
• Refractive Index: 1.684
• Boiling Point: 348.7 °C at 760 mmHg
• PKA: 2.68±0.30(Predicted)
• Flash Point: 164.7 °C
• PSA: 50.19000
• Density: 1.339 g/cm³
• LogP: 1.93300
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Quinolinecarboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Quinolinecarboxylic acid is a reactant used in the chemical & genetic engineering of selective ion channel-ligand interactions.

Technology Process of 7-Quinolinecarboxylic acid

There total 13 articles about 7-Quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

quinoline-7-carboxylic acid methyl ester (51552-68-2) → quinoline-7-carboxylic acid (1078-30-4)

Guidance literature:

quinoline-7-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; water; pH=7;

Reference yield: 60.0%

7-methylquinoline (612-60-2) → quinoline-7-carboxylic acid (1078-30-4)

Guidance literature:

With N-hydroxyphthalimide; oxygen; Nitrogen dioxide; cobalt(II) acetate; manganese(II) acetate; In acetic acid; at 110 ℃; for 15h; under 760.051 Torr;

DOI:10.1039/b108880g

Reference yield: 41.0%

1,2,3,4-tetrahydro-quinoline-7-carboxylic acid (22048-88-0) → quinoline-7-carboxylic acid (1078-30-4)

Guidance literature:

With hexagonal boron carbon nitride; In water; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201800319

upstream raw materials:

quinoline

7-methylquinoline

7-ethylquinoline

quinoline-7-carbonitrile

Downstream raw materials:

quinoline-7-carboxylic acid ethyl ester

quinoline-7-carboxylic acid methyl ester

7-ethylquinoline

1-(quinolin-7-yl)ethan-1-one

Refernces

• 1、 Tulyaganov, T. S.,Ibragimov, A. A.,Yunusov, S. Yu.. "ALKALOIDS OF Nitraria komarovii. VII. STRUCTURE AND SYNTHESIS OF KOMAROVININE". . p. 604 - 605. Retrieved 1982.
• 2、 Sakaguchi, Satoshi,Shibamoto, Akihiro,Ishii, Yasutaka. "Remarkable effect of nitrogen dioxide for N-hydroxyphthalimide-catalyzed aerobic oxidation of methylquinolines". . p. 180 - 181. Retrieved 2007/10/03.