4-FLUORO-2-(TRIFLUOROMETHYL)PHENOL

Base Information

• Chemical Name: 4-FLUORO-2-(TRIFLUOROMETHYL)PHENOL
• CAS No.: 130047-19-7
• Molecular Formula: C₇H₄F₄O
• Molecular Weight: 180.102
• Hs Code.: 2908199090
• Mol file: 130047-19-7.mol

Synonyms:2-(Trifluoromethyl)-4-fluorophenol;

Chemical Property of 4-FLUORO-2-(TRIFLUOROMETHYL)PHENOL

Chemical Property:

• Vapor Pressure: 1.17mmHg at 25°C
• Melting Point: 50-54℃
• Refractive Index: 1.44
• Boiling Point: 169.3 °C at 760 mmHg
• PKA: 7.99±0.43(Predicted)
• Flash Point: 56.2 °C
• PSA: 20.23000
• Density: 1.434 g/cm³
• LogP: 2.55010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Fluoro-2-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-2-(TRIFLUOROMETHYL)PHENOL

There total 1 articles about 4-FLUORO-2-(TRIFLUOROMETHYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H10F4O → 4-fluoro-2-(trifluoromethyl)phenol (130047-19-7)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; for 1.5h; Reflux;

DOI:10.1080/10426500802253090

Reference yield: 54.25%

2-benzyl-5-bromo-1,2,3,4-tetrahydro-2,6-naphthyridine (601514-63-0) + 4-fluoro-2-(trifluoromethyl)phenol (130047-19-7) → 2-benzyl-5-[4-fluoro-2-(trifluoromethyl)phenoxy]-1,2,3,4-tetrahydro-2,6-naphthyridine

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; In dimethyl sulfoxide; at 120 ℃; for 1h; Microbiological reaction;

Reference yield: 36.17%

tert-butyl 4-bromo-5,6,7,8-tetrahydro-1,7-naphthyridine-7-carboxylate + 4-fluoro-2-(trifluoromethyl)phenol (130047-19-7) → 4-[4-fluoro-2-(trifluoromethyl)phenoxy]-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; caesium carbonate; In dimethyl sulfoxide; Heating; Inert atmosphere;

Downstream raw materials:

2-({(2S)-1-[4-Fluoro-2-(trifluoromethyl)phenoxy]propan-2-yl}amino)ethanol, hydrochloride salt

(2S)-1-[4-fluoro-2-(trifluoromethyl)phenoxy]propan-2-amine

(2S)-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-[4-fluoro-2-(trifluoromethyl)phenoxy]propan-2-amine

Refernces