2-amino-N-methyl-N-phenylacetamide

Base Information

• Chemical Name: 2-amino-N-methyl-N-phenylacetamide
• CAS No.: 126866-37-3
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Hs Code.: 2924299090
• European Community (EC) Number: 674-688-1
• DSSTox Substance ID: DTXSID30472074
• Wikidata: Q82300847
• Mol file: 126866-37-3.mol

Synonyms:126866-37-3;2-amino-N-methyl-N-phenylacetamide;2-Amino-N-methyl-N-phenyl-acetamide;Acetamide, 2-amino-N-methyl-N-phenyl-;N-methyl 2-amino acetanilide;SCHEMBL4294754;DTXSID30472074;RXBFSGCVJMHEIV-UHFFFAOYSA-N;MFCD08060137;AKOS005135657;AS-63250;CS-0313292;FT-0653999;E79012;A805620

Chemical Property of 2-amino-N-methyl-N-phenylacetamide

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 269.514 °C at 760 mmHg
• Flash Point: 116.798 °C
• PSA: 46.33000
• Density: 1.135 g/cm³
• LogP: 1.30840
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 153

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-N-methyl-N-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)C(=O)CN
• Uses: 2-Amino-N-methyl-N-phenylacetamide is used as a reactant in the design and synthesis of novel diamide derivatives of glycine as antihyperglycemic agents.

Technology Process of 2-amino-N-methyl-N-phenylacetamide

There total 3 articles about 2-amino-N-methyl-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

→ 2-amino-N-methyl-N-phenylacetamide (126866-37-3)

Guidance literature:

Reference yield:

N-methyl-2-chloroacetanilide (2620-05-5) → 2-amino-N-methyl-N-phenylacetamide (126866-37-3)

Guidance literature:

With ammonia; sodium hydroxide; In ethanol; water; at 95 ℃; pH=10;

DOI:10.1016/j.tetlet.2015.01.046

Reference yield:

N-methylaniline (100-61-8) → 2-amino-N-methyl-N-phenylacetamide (126866-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: ammonia; sodium hydroxide / ethanol; water / 95 °C / pH 10

With ammonia; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1016/j.tetlet.2015.01.046

upstream raw materials:

N-methylaniline

N-methyl-2-chloroacetanilide

Downstream raw materials:

2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide

Refernces

• 1、 -. "Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors". Page 57. . Retrieved 2010/02/06.