Cori ester

Base Information

• Chemical Name: Cori ester
• CAS No.: 56401-20-8
• Molecular Formula: C6H13 O9 P . 2 Na
• Molecular Weight: 304.101
• Hs Code.: 29400090
• European Community (EC) Number: 260-154-1
• Mol file: 56401-20-8.mol

Synonyms:alpha-D-glucopyranose 1-phosphate

Chemical Property of Cori ester

Chemical Property:

• Vapor Pressure: 4.68E-17mmHg at 25°C
• Melting Point: 138°C
• Boiling Point: 603°Cat760mmHg
• Flash Point: 318.5°C
• PSA: 181.61000
• Density: 1.9g/cm³
• LogP: -2.29230
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 2
• Exact Mass: 322.00417217
• Heavy Atom Count: 19
• Complexity: 266

Purity/Quality:

98%,99%, ^*data from raw suppliers

b-D-Glucose-1-phosphate Disodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)OP(=O)([O-])[O-])O)O)O)O.O.[Na+].[Na+]
• Isomeric SMILES: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)OP(=O)([O-])[O-])O)O)O)O.O.[Na+].[Na+]
• Uses: alpha-D-Glucose-1-phosphate disodium salt tetra hydrate is a glucose molecule that can be used in cellular catabolism. It is used as an intermediate in chemical and pharmaceutical research.

Technology Process of Cori ester

There total 6 articles about Cori ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

D-glucose pentaacetate (83-87-4,604-68-2,604-69-3,2152-77-4,4026-35-1,4163-59-1,4163-60-4,4163-61-5,4163-65-9,4257-94-7,4257-96-9,16299-15-3,19186-39-1,19189-55-0,25878-60-8,25941-03-1,32445-48-0,32445-49-1,32445-53-7,32445-54-8,34685-58-0,34685-59-1,43168-42-9,43168-44-1,43169-22-8,43169-25-1,66966-07-2,70749-17-6,80184-01-6,93221-01-3,93221-02-4,99630-88-3,109215-53-4,115792-70-6,115792-73-9,139894-92-1,139973-25-4,144071-49-8,147648-81-5) → α-D-Glucopyranoside 1-(disodium phosphate) (56401-20-8)

Guidance literature:

D-glucose pentaacetate; With phosphoric acid; In melt; at 50 ℃; for 3h; under 1.20012 Torr; Inert atmosphere; Schlenk technique; Sealed tube;

With lithium hydroxide; In melt; water; at 0 - 20 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

In water; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1016/j.carres.2019.107896

Reference yield:

2,3,4,5-tetra-O-acetyl-D-glucopyranose (3947-62-4,6207-76-7,19235-21-3,22554-70-7,22860-22-6,47339-09-3,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,10343-06-3) → D-glucose-1-phosphate disodium salt (16450-65-0,17364-14-6,32972-46-6,56401-20-8,83833-15-2,93839-96-4,99749-54-9,104990-74-1,112820-40-3,147072-63-7,147072-64-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / 1,2,4-triazole / CH₂Cl₂ / 2 h / Ambient temperature

2: 98 percent / 30percent H₂O₂ / tetrahydrofuran / 1.5 h / Ambient temperature

3: H₂, 10percent NaHCO₃ / 5percent Pd/C / ethanol / 10 h / 760.2 Torr / Ambient temperature

4: 1N NaOH / 3 h / Ambient temperature

With 1,2,4-Triazole; sodium hydroxide; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

dibenzyl 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl phosphite (149717-36-2) → D-glucose-1-phosphate disodium salt (16450-65-0,17364-14-6,32972-46-6,56401-20-8,83833-15-2,93839-96-4,99749-54-9,104990-74-1,112820-40-3,147072-63-7,147072-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / 30percent H₂O₂ / tetrahydrofuran / 1.5 h / Ambient temperature

2: H₂, 10percent NaHCO₃ / 5percent Pd/C / ethanol / 10 h / 760.2 Torr / Ambient temperature

3: 1N NaOH / 3 h / Ambient temperature

With sodium hydroxide; hydrogen; dihydrogen peroxide; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

upstream raw materials:

D-glucose pentaacetate

2,3,4,5-tetra-O-acetyl-D-glucopyranose

dibenzyl 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl phosphite

dibenzyl 2,3,4,6-tetra-O-acetyl-D-glucopyranosyl phosphate

Downstream raw materials:

UDP-glucose

Potassium α-D-glucopyranosiduronate 1-(dipotassium phosphate)

2-phenylethyl-β-D-glucopyranoside

n-hexyl-β-D-glucopyranoside

Refernces

• 1、 Sim, Mui Mui,Kondo, Hirosato,Wong, Chi-Huey. "Synthesis and use of glycosyl phosphites: An effective route to glycosyl phosphates, sugar nucleotides, and glycosides". . p. 2260 - 2267. Retrieved 2007/10/02.