3-Chloro-4-hydroxyphenylboronic acid

Base Information

• Chemical Name: 3-Chloro-4-hydroxyphenylboronic acid
• CAS No.: 182344-13-4
• Molecular Formula: C6H6BClO3
• Molecular Weight: 172.376
• Hs Code.: 2931900090
• Mol file: 182344-13-4.mol

Synonyms:Boronicacid, (3-chloro-4-hydroxyphenyl)- (9CI);3-Chloro-4-hydroxyphenylboronic acid;(3-chloro-4-hydroxyphenyl)boronic acid;(3-Chloro-4-hydroxyphenyl)boronic acid;boronic acid, B-(3-chloro-4-hydroxyphenyl)-;

Chemical Property of 3-Chloro-4-hydroxyphenylboronic acid

Chemical Property:

• Vapor Pressure: 7.91E-06mmHg at 25°C
• Melting Point: 223-228°C
• Refractive Index: 1.602
• Boiling Point: 360.6 °C at 760 mmHg
• Flash Point: 171.9 °C
• PSA: 60.69000
• Density: 1.49 g/cm³
• LogP: -0.27460
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 3-Chloro-4-hydroxyphenylboronic acid

There total 1 articles about 3-Chloro-4-hydroxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

4-bromo-2-chlorophenol (3964-56-5) → (3-chloro-4-hydroxyphenyl)boronic acid (182344-13-4)

Guidance literature:

4-bromo-2-chlorophenol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

With Trimethyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 19h;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃;

Reference yield: 87.0%

(3-chloro-4-hydroxyphenyl)boronic acid (182344-13-4) + tert-butyl (3S)-3-((6-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)oxy)pyrrolidine-1-carboxylate → tert-butyl (3S)-3-((6-(3-chloro-4-hydroxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)oxy)pyrrolidine-1-carboxylate

Guidance literature:

With 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; water; at 110 ℃; for 2h; Inert atmosphere;

Reference yield: 74.0%

(3-chloro-4-hydroxyphenyl)boronic acid (182344-13-4) + 6-chloro-5-phenylpyrazin-2-amine (1357159-12-6) → 4-(6-amino-3-phenylpyrazin-2-yl)-2-chlorophenol

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 150 ℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;

upstream raw materials:

4-bromo-2-chlorophenol

Downstream raw materials:

methyl 2-(3-chloro-4-hydroxyphenyl)-7-(4-methylpiperazin-1-yl)-5H-pyrido[3,2-b]indole-4-carboxylate

6-((1H-1,2,4-triazol-1-yl)methyl)-3'-chloro-4'-hydroxybiphenyl-3-carbonitrile

[5-(3-chloro-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone

6-(3-chloro-4-hydroxyphenyl)-1-naphthol

Refernces

• 1、 -. "1,2,4-TRIAZOL-l-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMOURS". Page/Page column 120-121; 148-149; 152-153; 154-155. . Retrieved 2008/06/13.