1H-Indol-1-amine

Base Information

• Chemical Name: 1H-Indol-1-amine
• CAS No.: 53406-38-5
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Hs Code.: 2933998090
• Mol file: 53406-38-5.mol

Synonyms:1-Aminoindole;

Chemical Property of 1H-Indol-1-amine

Chemical Property:

• Vapor Pressure: 0.00146mmHg at 25°C
• Melting Point: 40 °C
• Refractive Index: 1.638
• Boiling Point: 296.208 °C at 760 mmHg
• PKA: 7.05±0.70(Predicted)
• Flash Point: 132.942 °C
• PSA: 30.95000
• Density: 1.183 g/cm³
• LogP: 1.93630
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Aminoindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indol-1-amine

There total 8 articles about 1H-Indol-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 1H-indol-1-amine (53406-38-5)

Guidance literature:

Reference yield: 88.0%

indole (120-72-9) + hydroxylamine-O-sulfonic acid (2950-43-8) → 1H-indol-1-amine (53406-38-5)

Guidance literature:

indole; hydroxylamine-O-sulfonic acid; With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 10 - 30 ℃; for 3.125h; Inert atmosphere; Large scale reaction;

Large scale reaction;

DOI:10.1021/op100330h

Reference yield: 73.0%

indole (120-72-9) → 1H-indol-1-amine (53406-38-5)

Guidance literature:

indole; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With chloroamine; tert-butyl methyl ether; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

DOI:10.1021/jo035587p

upstream raw materials:

indole

3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one

3-nitro-4-chloropyridine hydrochloride

2-Chloro-3-nitropyridine

Downstream raw materials:

C₂₂H₂₀N₂O₂

C₂₀H₁₇N₃O

N-phenyl-1H-indol-1-amine

N-(3-methoxyphenyl)-1H-indol-1-amine

Refernces

• 1、 Kornicka, Anita,Wasilewska, Aleksandra,S?czewski, Jaros?aw,Hudson, Alan L.,Boblewski, Konrad,Lehmann, Artur,Gzella, Karol,Belka, Mariusz,S?czewski, Franciszek,Gdaniec, Maria,Rybczyńska, Apolonia,B?czek, Tomasz. "1-[(Imidazolidin-2-yl)imino]-1H-indoles as new hypotensive agents: synthesis and in vitro and in vivo biological studies". . p. 400 - 410. Retrieved 2017/04/03.
• 2、 Weiberth, Franz J.,Hanna, Reda G.,Lee, George E.,Polverine, Yvonne,Klein, Joseph T.. "N-amination of indoles on pilot-plant scale via simultaneous and proportional metering of reagents". experimental part. p. 704 - 709. Retrieved 2011/12/04.