(S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride

Base Information

• Chemical Name: (S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride
• CAS No.: 51600-24-9
• Molecular Formula: C₁₂H₁₃N*ClH
• Molecular Weight: 207.703
• Hs Code.: 2921499090
• European Community (EC) Number: 621-653-3
• DSSTox Substance ID: DTXSID40965927
• Mol file: 51600-24-9.mol

Synonyms:51600-24-9;(S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride;(S)-1-(Naphthalen-1-yl)ethanamine hydrochloride;(s)-(-)-1-(1-naphthyl)ethylamine hcl;(1S)-1-naphthalen-1-ylethanamine;hydrochloride;(1S)-1-(naphthalen-1-yl)ethan-1-amine hydrochloride;(S)-(-)-1-(1-NAPHTHYL)ETHYLAMINE HYDROC&;DTXSID40965927;BCA60024;MFCD07369797;AKOS027430467;AS-48150;CS-0343291;F19297;(S)-(-)-1-(1-Naphthyl)ethylaminehydrochloride;(S)-1-(Naphthalen-1-yl)ethanaminehydrochloride;(S)-(^')-1-(1-Naphthyl)ethylamine hydrochloride;(S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride, 97%;1-(Naphthalen-1-yl)ethan-1-amine--hydrogen chloride (1/1)

Chemical Property of (S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 9.54E-05mmHg at 25°C
• Melting Point: 253-257 °C(lit.)
• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 155.7 °C
• PSA: 26.02000
• LogP: 4.36180
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 207.0814771
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-(?)-1-(1-Naphthyl)ethylamine hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC2=CC=CC=C21)N.Cl
• Isomeric SMILES: C[C@@H](C1=CC=CC2=CC=CC=C21)N.Cl

Technology Process of (S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride

There total 2 articles about (S)-(-)-1-(1-Naphthyl)ethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C12H11N*ClH (1164111-50-5) → (S)-<1-(1-Naphthyl)ethyl>ammonium chloride (51600-24-9)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; zhaophos; hydrogen; In isopropyl alcohol; at 25 ℃; for 24h; under 7600.51 Torr; enantioselective reaction; Inert atmosphere; Glovebox; Autoclave;

DOI:10.1002/anie.201404570

Reference yield:

→ (S)-<1-(1-Naphthyl)ethyl>ammonium chloride (51600-24-9)

Guidance literature:

entspr. Amin (S)-5a, HCl;

DOI:10.1021/jo00929a048

Reference yield:

(S)-<1-(1-Naphthyl)ethyl>ammonium chloride (51600-24-9) → N-(2-(((S)-1-(naphthalen-1-yl)ethyl)amino)-2-oxo-1-( pyridin-3-yl)ethyl)-N-(prop-2-yn-1-yl)benzamide

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / 1 h / 100 °C / Microwave irradiation

2: 4-methyl-morpholine; bis(trichloromethyl) carbonate / dichloromethane / 3.17 h / -78 - 30 °C

3: indium(III) chloride / methanol / 2 h / 50 °C / Microwave irradiation

With 4-methyl-morpholine; indium(III) chloride; bis(trichloromethyl) carbonate; triethylamine; In methanol; dichloromethane; 3: |Ugi Condensation;

DOI:10.1039/c4ob00767k

upstream raw materials:

C₁₂H₁₁N*ClH

Refernces