2-AMINO-5-PHENYLPYRAZINE

Base Information

• Chemical Name: 2-AMINO-5-PHENYLPYRAZINE
• CAS No.: 13535-13-2
• Molecular Formula: C10H9N3
• Molecular Weight: 171.202
• Hs Code.: 2933990090
• Mol file: 13535-13-2.mol

Synonyms:Pyrazinamine,5-phenyl- (9CI);Pyrazine, 2-amino-5-phenyl- (8CI);(5-Phenylpyrazin-2-yl)amine;5-Phenyl-2-aminopyrazine;5-Phenylpyrazin-2-amine;

Chemical Property of 2-AMINO-5-PHENYLPYRAZINE

Chemical Property:

• Vapor Pressure: 9.28E-05mmHg at 25°C
• Melting Point: 146 °C
• Refractive Index: 1.633
• Boiling Point: 339.298 °C at 760 mmHg
• PKA: 2.98±0.10(Predicted)
• Flash Point: 185.644 °C
• PSA: 51.80000
• Density: 1.193 g/cm³
• LogP: 2.30700
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-Phenylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/38-43
• Safety Statements: 22-24/25-26-36/37-39-51

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-PHENYLPYRAZINE

There total 10 articles about 2-AMINO-5-PHENYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-amino-2-bromopyrazine (59489-71-3) + phenylboronic acid (98-80-6) → 2-amino-5-phenylpyrazine (13535-13-2)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; at 150 ℃; for 0.166667h; microwave reactor;

Reference yield: 92.0%

→ 2-amino-5-phenylpyrazine (13535-13-2)

Guidance literature:

Reference yield: 91.0%

2-amino-3-cyano-5-phenylpyrazine-1-N-oxide (50627-20-8) → 2-amino-5-phenylpyrazine (13535-13-2)

Guidance literature:

With hydrogen; acetic acid; platinum on activated charcoal; Darco KB-B; In methanol; at 40 ℃; for 18h; under 2068.59 Torr;

DOI:10.1016/S0040-4039(02)01499-5

upstream raw materials:

2-Chloro-5-phenyl-pyrazine

2-amino-3-cyano-5-phenylpyrazine-1-N-oxide

E-isonitrosoacetophenone

2-aminoacetonitrile hydrochloride

Downstream raw materials:

C₂₁H₂₁N₅O₃

3-acetamido-6-phenylpyrazine

N-(5-phenylpyrazin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine

2-benzyl-6-phenyl-8-(phenylthio)imidazo[1,2-a]pyrazin-3(7H)-one

Refernces

• 1、 Yuan, Ming-Liang,Jiang, Tian-Yu,Du, Lu-Pei,Li, Min-Yong. "Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation". supporting information. p. 550 - 554. Retrieved 2016/04/26.
• 2、 -. "WNT PATHWAY MODULATORS". Paragraph 0251; 0252; 0255; 0256. . Retrieved 2015/07/07.