4-Pyridinecarbonitrile,3-fluoro-(9CI)

Base Information

• Chemical Name: 4-Pyridinecarbonitrile,3-fluoro-(9CI)
• CAS No.: 113770-88-0
• Molecular Formula: C6H3FN2
• Molecular Weight: 122.102
• Hs Code.: 2933399090
• Mol file: 113770-88-0.mol

Synonyms:4-Pyridinecarbonitrile,3-fluoro-(9CI);4-Cyano-3-fluoropyridine;3-Fluoropyridine-4-carbonitrile;3-Fluoro-4-pyridinecarbonitrile;4-Pyridinecarbonitrile,3-fluoro-

Chemical Property of 4-Pyridinecarbonitrile,3-fluoro-(9CI)

Chemical Property:

• Vapor Pressure: 0.972mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 178.802 °C at 760 mmHg
• PKA: -0.55±0.18(Predicted)
• Flash Point: 61.937 °C
• PSA: 36.68000
• Density: 1.249 g/cm³
• LogP: 1.09238
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-4-cyanopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Cyano-3-fluoropyridine is used as pharmaceutical intermediate.

Technology Process of 4-Pyridinecarbonitrile,3-fluoro-(9CI)

There total 1 articles about 4-Pyridinecarbonitrile,3-fluoro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-fluoro-4-pyridinecarbonitrile (113770-88-0)

Guidance literature:

Reference yield: 100.0%

3-fluoro-4-pyridinecarbonitrile (113770-88-0) → 1H-pyrazolo[3,4-c]pyridin-3-amine (76006-17-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 70 ℃; for 16h;

Reference yield: 94.0%

3-fluoro-4-pyridinecarbonitrile (113770-88-0) + 1-Phenyl-pentylideneamine; hydrochloride → C16H19FN2

Guidance literature:

With tetraethylammonium chloride; In dimethyl sulfoxide; at 20 ℃; for 10.72h; Glovebox; Inert atmosphere; Electrochemical reaction;

DOI:10.1021/jacs.9b10870

Downstream raw materials:

3-[(1-cyclohexyl-1-methylethyl)amino]-4-pyridinecarboxylic acid

3-[(1-cyclohexyl-1-methylethyl)amino]-4-pyridinecarbonitrile

1H-pyrazolo[3,4-c]pyridin-3-amine

isoxazolo[5,4-c]pyridin-3-amine

Refernces

• 1、 -. "CATALYTIC METHOD FOR PRODUCING FLUOROAROMATIC COMPOUNDS USING BRANCHED ALKYL PYRIDINIUM SALTS". . . Retrieved 2008/06/13.
• 2、 -. "Preparation of fluoroaromatic compounds in dispersion of potassium fluoride". . . Retrieved 2008/06/13.