4-Ethoxy-β,β'-dibromostyrene

Base Information

• Chemical Name: 4-Ethoxy-β,β'-dibromostyrene
• CAS No.: 415967-68-9
• Molecular Formula: C₁₀H₁₀Br₂O
• Molecular Weight: 305.997
• Mol file: 415967-68-9.mol

Synonyms:4-Ethoxy-β,β'-dibromostyrene

Chemical Property of 4-Ethoxy-β,β'-dibromostyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Ethoxy-β,β'-dibromostyrene

There total 1 articles about 4-Ethoxy-β,β'-dibromostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

carbon tetrabromide (558-13-4) + 4-ethoxybenzaldehyde (10031-82-0) → 4-Ethoxy-β,β'-dibromostyrene (415967-68-9)

Guidance literature:

carbon tetrabromide; With triphenylphosphine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

4-ethoxybenzaldehyde; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

Reference yield: 72.0%

methyl chloroformate (79-22-1) + 4-Ethoxy-β,β'-dibromostyrene (415967-68-9) → C13H14O3

Guidance literature:

4-Ethoxy-β,β'-dibromostyrene; With n-butyllithium; In diethyl ether;

methyl chloroformate; In diethyl ether; Further stages.;

DOI:10.1016/j.tetlet.2006.12.045

Reference yield: 51.0%

N-phenylbenzamidine (1527-91-9) + 4-Ethoxy-β,β'-dibromostyrene (415967-68-9) → 5-bromo-4-(4-ethoxyphenyl)-1,2-diphenyl-1H-imidazole

Guidance literature:

4-Ethoxy-β,β'-dibromostyrene; With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 80 ℃; Schlenk technique;

N-phenylbenzamidine; With bathophenanthroline; copper(l) chloride; In N,N-dimethyl-formamide; at 100 ℃; stereoselective reaction; Schlenk technique;

DOI:10.1002/ejoc.201500305

upstream raw materials:

carbon tetrabromide

4-ethoxybenzaldehyde

Downstream raw materials:

2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine

Refernces

• 1、 -. "FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTIVE AGENTS". Paragraph 0262; 0263; 0268; 0269. . Retrieved 2015/02/18.
• 2、 Whitehead, Andrew J.,Ward, Richard A.,Jones, Martin F.. "Efficient synthesis of the selective COX-2 inhibitor GW406381X". . p. 911 - 913. Retrieved 2008/02/04.