2,4-Dimethylpyridin-3-amine

Base Information

• Chemical Name: 2,4-Dimethylpyridin-3-amine
• CAS No.: 1073-21-8
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 835-964-9
• DSSTox Substance ID: DTXSID10565276
• Wikidata: Q72436378
• Mol file: 1073-21-8.mol

Synonyms:2,4-dimethylpyridin-3-amine;3-Amino-2,4-dimethylpyridine;1073-21-8;MFCD08235192;3-PYRIDINAMINE, 2,4-DIMETHYL-;2,4-dimethyl-3-aminopyridine;SCHEMBL580504;2,4-Dimethyl-pyridin-3-ylamine;DTXSID10565276;TQP0097;FSYHJEBPLDNXAM-UHFFFAOYSA-N;AKOS006339511;AB43810;PS-5876;3-amino-2,4-dimethylpyridine, AldrichCPR;CS-0130718;EN300-206276;A801669;W-200762;Z1203578937

Chemical Property of 2,4-Dimethylpyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.016mmHg at 25°C
• Melting Point: 53 °C
• Refractive Index: 1.564
• Boiling Point: 255.708 °C at 760 mmHg
• PKA: 7.54±0.18(Predicted)
• Flash Point: 132.153 °C
• PSA: 38.91000
• Density: 1.04 g/cm³
• LogP: 1.86180
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 92.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-2,4-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)C)N
• Uses: 3-Amino-2,4-dimethylpyridine is a useful reagent for the synthesis and studies of diazepines and derivatives.

Technology Process of 2,4-Dimethylpyridin-3-amine

There total 7 articles about 2,4-Dimethylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,4-dimethyl-3-nitropyridine (1074-76-6) → 3-amino-2,4-dimethylpyridine (1073-21-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 3102.9 Torr;

DOI:10.1021/jm00098a011

Reference yield: 92.0%

6-chloro-2,4-dimethyl-3-nitropyridine (89793-08-8) → 3-amino-2,4-dimethylpyridine (1073-21-8)

Guidance literature:

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; under 2206.5 Torr;

Reference yield: 74.0%

2,4-dimethylnicotinic acid (55314-30-2) → 3-amino-2,4-dimethylpyridine (1073-21-8)

Guidance literature:

2,4-dimethylnicotinic acid; With thionyl chloride; at 60 ℃; for 1h;

With sodium azide; water; In acetone; at 70 ℃; for 1h;

upstream raw materials:

2,4-dimethyl-3-nitropyridine

6-chloro-2,4-dimethyl-3-nitropyridine

3-nitro-6-hydroxy-2,4-dimethylpyridine

2,4-lutidine

Downstream raw materials:

2,4-dimethyl-pyridin-3-ol

2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-5,6,7,8-tetrahydro(5,5-²H₂)-1,6-naphthyridine

2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one

2-(2,6-diethylphenyl)-6-(2,4-dimethylpyridin-3-yl)-4-methyl-1,6-naphthyridin-5(6H)-one

Refernces

• 1、 -. "DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS". Page/Page column 20. . Retrieved 2009/01/24.
• 2、 -. "2-formylpyridine thiosemicarbazone compounds". . . Retrieved 2008/06/13.